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International Symposium: Retroviruses and Human Pathology

  • Robert C. Gallo
  • Dominique Stehelin
  • Oliviero E. Varnier

Part of the Experimental Biology and Medicine book series (EBAM, volume 11)

Table of contents

  1. Front Matter
    Pages i-xxiii
  2. Introduction: The Role of Retroviruses

    1. Front Matter
      Pages xxiii-xxiii
    2. Carmine A. Romanzi
      Pages 1-1
    3. N. Oker-Blom, S. Pfeifer-Ohlsson, K. Alitalo
      Pages 3-17
    4. R. Dulbecco
      Pages 19-33
  3. W. P. Rowe Memorial Lecture

    1. Front Matter
      Pages 34-34
    2. J. A. Levy
      Pages 35-59
  4. Retroviruses and the Murine Model System

  5. Retroviruses and the Vertebrate Model System

    1. Front Matter
      Pages 151-151
    2. S. Rasheed
      Pages 153-175
    3. O. Jarrett
      Pages 193-202
    4. A. Burny, C. Bruck, Y. Cleuter, D. Couez, J. Deschamps, J. Ghysdael et al.
      Pages 203-216
    5. P. J. Chen, A. Cywinski, J. M. Taylor
      Pages 227-234
    6. L. Thiry, S. Sprecher-Goldberger, J. Cogniaux-LeClerc, A. Burny, D. Portetelle, H. A. Blough
      Pages 235-242
    7. U. T. Banders, J. A. Meldrajs, V. V. Konicheva, V. P. Lozha, R. A. Kukaine
      Pages 243-249
    8. V. Wunderlich, W. Uckert, J. Denner, D. Bierwolf
      Pages 251-257
    9. G. Ivaldi, P. Pippia, S. Rasheed, O. Muratore, S. P. Raffanti, B. Azzarone et al.
      Pages 259-262
  6. Retroviruses and Human Pathology

    1. Front Matter
      Pages 263-263
    2. A. Vaheri, J. Suni, A. Narvanen, R. Pakkanen, T. Wahlstrom
      Pages 275-290
    3. J. C. Chermann, F. Barre-Sinoussi, L. Montagnier
      Pages 291-299
    4. R. Callahan, I. Ali, J. Fetherston, T. Horn, J. Schlom
      Pages 319-332
    5. L. Gazzolo, M. Duc Dodon, A. Gessain, M. Robert-Guroff, G. de-The
      Pages 353-361
    6. H. L. Ioachim, W. J. Cronin, B. H. Dorsett, D. Triglia, F. C. Jensen
      Pages 363-370
    7. J. Goudsmit, M. Gravell, F. W. van der Walls, J. L. Sever, C. J. Gibbs Jr, D. C. Gajdusek
      Pages 381-384
    8. E. Larsson, I. Suni, A. Vaheri, P. Sundstrom, O. Nilsson
      Pages 385-393
    9. O.-J. Iversen, A. B. Dalen
      Pages 395-400
  7. Retroviruses and Oncogenes

    1. Front Matter
      Pages 415-415
    2. D. Stehelin, P. Martin
      Pages 417-424
    3. H. Zarbl, S. Sukumar, D. Martin-Zanca, E. Santos, M. Barbacid
      Pages 425-447
    4. U. R. Rapp, T. I. Bonner, J. L. Cleveland
      Pages 449-472
    5. B. Azzarone, G. Carloni, M. Mareel, O. E. Varnier, A. Macieira-Coelho
      Pages 473-483
    6. K. Alitalo, J. Keski-Oja, K. Saksela, R. Winqvist
      Pages 485-495

About this book

Introduction

For decades retroviruses have been riding the crest of a wave of experimental research directed toward the identification of an infectious agent of human neoplastic diseases. In the early 1970s, several scientists successfully demonstrated the presence of retroviruses in numerous animal species and proved their etiological role in some related diseases. Corresponding findings in humans were somewhat discouraging. Although financial support for this line· of research declined, a few dedicated retrovirologists survived and continued to collect more biological information and technological expertise that opened a new approach to the search for a human retrovirus. The rewards came with the discovery that the genes responsible for neoplastic transformation (oncogenes) are of cellular origin and can be shuttled about by retroviruses, and with the identification of a new family of Human T-cell Lymphotrophic retroViruses (HTLV) from patients with diseases ranging from leukemia to the acquired immunodeficiency syndrome (AIDS). An understanding of the role and significance of retroviruses in human pathology requires basic knowledge of the major animal systems studied. With this perspective in mind, we present here a survey that includes general overviews, minireviews on each animal system studied with selected experimental reports and, finally, a stimulating review of the field of human retrovirology by many of the pioneer scientists who created it. We are especially grateful to Profs. C. A. Romanzi and G. C. Schito for promoting the organization of the Symposium. On behalf of the Sym­ posium Committee, we thank E. Soeri, L. Casarino, G. P. Gesu, M.

Keywords

AIDS Antigen diseases histocompatibility immunodeficiency infection infections leukemia molecular biology pathology proteins psoriasis retroviruses virology virus

Editors and affiliations

  • Robert C. Gallo
    • 1
  • Dominique Stehelin
    • 2
  • Oliviero E. Varnier
    • 3
  1. 1.National Institutes of HealthBethesdaUSA
  2. 2.Institut PasteurLilleFrance
  3. 3.Istituto di MicrobiologiaUniversity of GenovaGenovaItalia

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