Human T Cell Clones

A New Approach to Immune Regulation

  • Marc Feldmann
  • Jonathan R. Lamb
  • James N. Woody

Part of the Experimental Biology and Medicine book series (EBAM, volume 9)

Table of contents

  1. Front Matter
    Pages i-xv
  2. T Cell Receptor

    1. Front Matter
      Pages 1-2
    2. Oreste Acuto, Marina Fabbi, Ellis L. Reinherz
      Pages 3-14
    3. Kathryn Haskins, Neal Roehm, Charles Hannum, Janice White, Ralph Kubo, Philippa Marrack et al.
      Pages 15-23
    4. Nicholas R. J. Gascoigne, Yueh-hsiu Chien, Phillip Patten, Daniel M. Becker, Tullia Lindsten, Joshua Kavaler et al.
      Pages 25-34
    5. Mary K. L. Collins, A. Maija Kissonerghis, M. Jenny Dunne, Michael J. Owen
      Pages 35-46
  3. HLA Antigens and Their Recognition

    1. Front Matter
      Pages 47-47
    2. John Trowsdale, Penelope Austin, Susan Carson, Adrian Kelly, Jonathan Lamb, John Young
      Pages 49-57
    3. T. Sasazuki, Y. Nishimura, K. Tsukamoto, K. Hirayama, T. Sone
      Pages 91-103
    4. Lesley E. Wallace, Melanie A. Houghton, Alan B. Rickinson
      Pages 105-114
  4. Clones Recognizing Extrinsic Antigens

    1. Front Matter
      Pages 115-116
    2. J. R. Lamb, M. Feldmann, N. Green, R. A. Lerner, E. D. Zanders
      Pages 117-124
    3. David J. Volkman, Thomas B. Nutman, Eric A. Ottesen, Anthony S. Fauci
      Pages 125-133
    4. Ann D. M. Rees, Glenda L. Knott, Paul N. Nelson, Nicola Dobson, Ruth Mathews, Peter W. Andrew
      Pages 135-145
    5. F. Sinigaglia, D. Scheidegger, A. Lanzavecchia, M. Pletscher, R. J. Scheper, G. Garotta
      Pages 163-170
  5. Role of Cell Surface Molecules in T Cell Function

    1. Front Matter
      Pages 171-172
    2. D. Olive, D. Charmot, P. Dubreuil, A. Tounkara, M. Ragueneau, C. Mawas et al.
      Pages 173-185
    3. Steven J. Mentzer, Julia L. Greenstein, Alan M. Krensky, Steven J. Burakoff
      Pages 187-196
    4. Nitin K. Damle, Dianne M. Fishwild, Nahid Mohagheghpour, Edgar G. Engleman
      Pages 197-208
    5. E. D. Zanders, M. Feldmann, K. O’Flynn, Shamshad Cockroft, J. R. Lamb
      Pages 209-217
    6. Alessandro Moretta, Giuseppe Pantaleo
      Pages 219-225
  6. T Cell Clones and the Analysis of Disease

    1. Front Matter
      Pages 227-228
    2. Marco Londei, G. Franco Bottazzo, Marc Feldmann
      Pages 239-250
    3. J. P. De Villartay, A. Fischer, C. Griscelli
      Pages 251-261
    4. R. C. Gallo, M. G. Sarngadharan, J. Schupbach, M. Popovic, P. Markham, S. Z. Salahuddin et al.
      Pages 263-275
  7. Immuneregulation

    1. Front Matter
      Pages 277-278
    2. Kendall A. Smith
      Pages 279-284
    3. Thomas A. Waldmann, Warren J. Leonard, Joel M. Depper, Martin Kronke, Carolyn K. Goldman, Kathleen Bongiovanni et al.
      Pages 285-300
    4. Marc Feldmann, E. D. Zanders, P. C. L. Beverley, J. R. Lamb
      Pages 301-307
    5. J. R. Lamb, Marc Feldmann, E. D. Zanders, P. C. L. Beverley
      Pages 309-315
    6. I. Ando, P. C. L. Beverley, D. H. Crawford, G. Hariri, M. A. Kissonerghis, M. J. Owen et al.
      Pages 341-345
  8. Regulatory Factors Produced by T Cell Clones

    1. Front Matter
      Pages 347-348
    2. T. Kishimoto, T. Hirano, H. Kikutani, A. Muraguchi, K. Shimizu, H. Kishi et al.
      Pages 349-359
    3. James N. Woody, Jonathan R. Lamb, Edward D. Zanders, Marc Feldman
      Pages 361-368
    4. Muzaffer Altin, Douglas G. Kilburn, Robert C. Miller Jr.
      Pages 369-379
    5. Phil Lake, Eve D. Robinson, Mark Brunswick, Lex Cowsert, Tran C. Chanh
      Pages 389-399
  9. T Cell Clones and Anti-Tumor Immunity

  10. Back Matter
    Pages 451-455

About this book


Most complex biological systems, such as enzyme pathways, are effec­ tively controlled near the beginning of the process. There is increasing evidence that the same is true for the immune system, with the initial interactions between antigen, antigen-presenting cells, and T cells hav­ ing a paramount influence on the ensuing events. Thus, analysis of the early stages of the immune responses has been a preoccupation of many immunologists. This has been considerably aided by the capac­ ity to expand these early events, and 'immortalize' them as clones of T cells, for detailed analysis. The discovery by Morgan, Ruscetti, and Gallo (Science 193, 1007, 1976) of T-cell growth factor (now termed interleukin-2 or IL-2) has had a major impact in immunology that is far from over. The greater ease of handling murine tissues experimentally, with the availability of more precisely defined reagents such as inbred strains, has meant that, to date, most of the work on long-term T-cell cultures has been per­ formed in the mouse, as summarized by Fathman and Fitch (eds. , Iso­ lation, Characterization and Utilization of T Lymphocyte Clones, Aca­ demic Press, NY, 1982). However, the limitations of working with human tissues are counterbalanced by the great long-term importance of understanding disorders of human immune regulation, especially since it is becoming evident that these are far from rare. Immune deficiencies such as agammaglobulinemia and T-cell deficiencies are not common, but immune hyperresponsiveness occurring in allergy and allergiC diseases (e. g.


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Editors and affiliations

  • Marc Feldmann
    • 1
  • Jonathan R. Lamb
    • 2
  • James N. Woody
    • 3
  1. 1.Imperial Cancer Research Fund, Tumour Immunology Unit, Department of ZoologyUniversity College LondonLondonUK
  2. 2.MRC Tuberculosis and Related InfectionsHammersmith HosptialLondonUK
  3. 3.Tissue BankNaval Medical Research InstituteBethesdaUSA

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