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Epstein-Barr Virus and Human Disease

  • Book
  • © 1987

Overview

Editors:
  1. P. H. Levine

    1. National Cancer Institute, Bethesda, USA

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  2. D. V. Ablashi

    1. National Cancer Institute, Bethesda, USA

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  3. M. Nonoyama

    1. Showa University Research Institute, St. Petersburg, USA

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  4. G. R. Pearson

    1. Georgetown University Medical Center, USA

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  5. R. Glaser

    1. The Ohio State University, Columbus, USA

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Part of the book series: Experimental Biology and Medicine (EBAM, volume 15)

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Table of contents (111 chapters)

  1. New Developments in Clinical Studies of EBV-Associated Diseases

    1. Cancer Risks and EBV Antibody Patterns in NPC Families

      • A. Lanier, S. Clift, B. Ireland, L. Knutson, D. Foster, A. Harpster et al.
      Pages 85-89

    2. EBV Related B Cell Lymphoproliferative Disease after T Depleted Mismatched Bone Marrow Transplantation

      • R. S. Shapiro, K. McClain, B. Blazar, J. Greenberg, D. Patton, K. Gajl-Peczalska et al.
      Pages 91-95

    3. T Cell Lymphomas in Patients with Chronic EBV Infection

      • James F. Jones, Susan Shurin, Carlos Abramowsky, Ben Katz, Jeff Sklar
      Pages 97-100

    4. Morbidity of Epstein-Barr Virus Infection in Children

      • W. M. Roberts, R. Wotherspoon, H. G. Herrod, J. Sixbey
      Pages 101-104

    5. Chronic active Epstein-Barr virus infection in children: heterogeneity in immune defects and EBNA-antibody pattern

      • W. Kuis, A. L. Young, A. B. Rickinson, E. R. de Graeff-Meeder, G. T. Rijkers, B. J. M. Zegers
      Pages 105-110

    6. P3HR-1-Like Nontransforming Virus in Saliva and Peripheral Blood Lymphocytes in Chronic Active EBV Infection

      • C. Alfieri, J. H. Joncas, N. Raab-Traub, J. Pagano
      Pages 111-115

    7. Development of Two Monoclonal B-Cell Lymphomas in a Patient with Wiskott-Aldrich Syndrome

      • Jack Davis, Beda Brichacek, David T. Purtilo, Hans Ochs
      Pages 117-118

    8. Detection of Epstein-Barr Virus DNA in Saliva of Patients with Aids and Related Disorders

      • G. Alsip, Y. Ench, C. Sumaya, R. N. Boswell
      Pages 119-120

    9. Detection in Normal Tonsils of a Novel B Lymphocyte Population with a Burkitt-Like Phenotype

      • M. Lipinski, C. Tétaud, M. Talbot, J. Wiels, B. Caillou, T. Tursz
      Pages 121-122

    10. Epstein-Barr Virus in the Lower Respiratory Tract

      • J. Almond, M. Lung, S. Y. So, W. K. Lam, M. H. Ng
      Pages 123-124

    11. Semiquantitative Analysis of Oropharyngeal EBV Shedding in Various Populations by Dot Blot Hybridization

      • R. F. Ambinder, W. H. Burns, P. Charache, A. Joffe, J. Nagel, M. C. Hochberg et al.
      Pages 125-126

    12. Prevalence of EBV in Household Contacts of Patients with Nasopharyngeal Carcinoma

      • S. D. Kottaridis, R. Goula, G. Stathopoulos
      Pages 127-129

    13. Changes in Lymphocyte Populations in Nasopharyngeal Carcinoma (NPC) Following Primary Radiotherapy with Subsequent a2-Interferon (IFN)-Therapy

      • G. Bertram, H. Ostmeier, S. Preyer, H. Wolf, G. R. F. Krueger
      Pages 131-133

    14. Some Questions Raised by Studies on Greenland Eskimos

      • P. Ebbesen, M. Melbye, P. H. Levine
      Pages 135-136

  2. EBV DNA and Gene Expression

    1. Front Matter

      Pages 137-137
      Download chapter PDF

    2. Effects of S-adenosylhomocysteine and Analogs on Epstein-Barr Virus (EBV)-Induced Transformation, EBV DNA Methylation and Gene Expression

      • Gerald Fronko, Earl Henderson, Brian Wu, Walter Long
      Pages 139-143

    3. Mapping EBV Early Antigens in Human Cells after Microinjection of Subgenomic DNA Clones

      • Ann Boyd, Ronald Glaser
      Pages 145-149

    4. Regulation of EBV Lytic Cycle Genes: MS-EA, a Trans-Activator of Gene Expression

      • P. M. Lieberman, M.-S. Cho, S. D. Hayward
      Pages 151-155

    5. An EBV Early Promoter is Activated by Two Viral Encoded Transacting Eactors EB1 and EB2

      • Anna Chevallier-Greco, E. Manet, P. Chavrier, G. Urier, M. Buisson, J. Daillie et al.
      Pages 157-161

    6. Regulation of EBV Promoters

      • Shannon Kenney, J. C. Lin, Joseph S. Pagano
      Pages 163-167
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Keywords

About this book

Since its discovery as the cause of infectious mononucleosis in 1964, the Epstein-Barr virus (EBV) has been etiologically implicated in an increasing number of human diseases. Generally considered the first human oncogenic virus because of a number of studies linking it with Burkitt's lymphoma and nasopharyngeal carcinoma (NPC), as well as its documented oncogenicity in nonhuman primates, EBVhas served as a model for identifying subsequent candidate oncogenic viruses and the stimulus for Evans' revision of the Henle-Koch postulates to accommodate the problems in proving viral oncogenicity in humans. Research on the role of EBV in human cancer was particularly en­ hanced (a) by the pioneering work of Werner and Gertrude Henle, and (b) by the coordinated efforts of the Special Virus Leukemia Program and its successors, the Special Virus Cancer Program and the Virus Cancer Program of the National Cancer Institute (NCI). Initiated by Dr. Frank J. Rauscher, who subsequently became director of the Ncr and is now Vice-President of the American Cancer Society, and expanded by Dr. John B. Moloney, whose contributions to cancer research were honored at this Second International Symposium on EBV and Associated Malignant Diseases, these NCI contract-sup­ ported programs brought together investigators from all over the world to participate in a joint effort to unravel the mystery of EBV behavior and pathogenicity. It was these programs that gave us the opportunity to work with such outstanding people as Professor Yohei Ito, to whom this book is dedicated.

Editors and Affiliations

  • National Cancer Institute, Bethesda, USA

    P. H. Levine, D. V. Ablashi

  • Showa University Research Institute, St. Petersburg, USA

    M. Nonoyama

  • Georgetown University Medical Center, USA

    G. R. Pearson

  • The Ohio State University, Columbus, USA

    R. Glaser

Bibliographic Information

  • Book Title: Epstein-Barr Virus and Human Disease

  • Editors: P. H. Levine, D. V. Ablashi, M. Nonoyama, G. R. Pearson, R. Glaser

  • Series Title: Experimental Biology and Medicine

  • DOI: https://doi.org/10.1007/978-1-4612-4590-2

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Humana Press Inc. 1987

  • Hardcover ISBN: 978-0-89603-130-2Published: 16 September 1987

  • Softcover ISBN: 978-1-4612-8940-1Published: 14 October 2011

  • eBook ISBN: 978-1-4612-4590-2Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XXXII, 530

  • Topics: Immunology

  • Industry Sectors: Biotechnology, Consumer Packaged Goods, Health & Hospitals, Pharma

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