Epstein-Barr Virus and Human Disease

  • P. H. Levine
  • D. V. Ablashi
  • M. Nonoyama
  • G. R. Pearson
  • R. Glaser

Part of the Experimental Biology and Medicine book series (EBAM, volume 15)

Table of contents

  1. Front Matter
    Pages i-xxxi
  2. Clinical Features of EBV-Associated Diseases

    1. Front Matter
      Pages 1-1
    2. S. Stosic, J. Marinkovic, M. Spalajkovic, B. Krejovic, G. de-Thé
      Pages 21-24
    3. G. de-The, F. de Vathaire, H. Sancho-Garnier, H. de-The, G. Schwaab, C. Micheau et al.
      Pages 43-45
    4. James F. Jones, Marshall Williams, Robert T. Schooley, Ronald Glaser
      Pages 49-52
    5. C. S. Yang, J. Y. Chen, M. Y. Liu, C. J. Chen, M. M. Hsu, T. C. Lynn et al.
      Pages 67-69
    6. F. de Vathaire, P. Herait, M. Lipinski, H. Sancho-Garnier, G. de Thé, T. Tursz
      Pages 71-72
    7. Raymond Frade, Alice Kahan, Christiane Charriaut-Marlangue, André Kahan, Monique Barel
      Pages 73-75
  3. New Developments in Clinical Studies of EBV-Associated Diseases

    1. Front Matter
      Pages 77-77
    2. S. Clift, A. Lanier, K. Kline, W. Henle, G. Henle, N. Raab-Traub
      Pages 79-83
    3. A. Lanier, S. Clift, B. Ireland, L. Knutson, D. Foster, A. Harpster et al.
      Pages 85-89
    4. R. S. Shapiro, K. McClain, B. Blazar, J. Greenberg, D. Patton, K. Gajl-Peczalska et al.
      Pages 91-95
    5. James F. Jones, Susan Shurin, Carlos Abramowsky, Ben Katz, Jeff Sklar
      Pages 97-100
    6. W. M. Roberts, R. Wotherspoon, H. G. Herrod, J. Sixbey
      Pages 101-104
    7. W. Kuis, A. L. Young, A. B. Rickinson, E. R. de Graeff-Meeder, G. T. Rijkers, B. J. M. Zegers
      Pages 105-110
    8. Jack Davis, Beda Brichacek, David T. Purtilo, Hans Ochs
      Pages 117-118
    9. G. Alsip, Y. Ench, C. Sumaya, R. N. Boswell
      Pages 119-120
    10. M. Lipinski, C. Tétaud, M. Talbot, J. Wiels, B. Caillou, T. Tursz
      Pages 121-122
    11. J. Almond, M. Lung, S. Y. So, W. K. Lam, M. H. Ng
      Pages 123-124
    12. R. F. Ambinder, W. H. Burns, P. Charache, A. Joffe, J. Nagel, M. C. Hochberg et al.
      Pages 125-126
    13. S. D. Kottaridis, R. Goula, G. Stathopoulos
      Pages 127-129
    14. P. Ebbesen, M. Melbye, P. H. Levine
      Pages 135-136
  4. EBV DNA and Gene Expression

    1. Front Matter
      Pages 137-137
    2. P. M. Lieberman, M.-S. Cho, S. D. Hayward
      Pages 151-155
    3. Anna Chevallier-Greco, E. Manet, P. Chavrier, G. Urier, M. Buisson, J. Daillie et al.
      Pages 157-161
    4. Shannon Kenney, J. C. Lin, Joseph S. Pagano
      Pages 163-167
    5. M. J. Allday, M. D. Jones, B. E. Griffin
      Pages 175-177
    6. Jen-Yang Chen, Yueh-Hsing Ou, Tswey-Ying Hsu, Mei-Ying Liu, Teh-Shiou Huang, Lei-Ron Jan et al.
      Pages 183-187
    7. H.-Y. Zhang, G. Qu, Z.-W. Deng, T.-H. Yao, R. Glaser
      Pages 189-190
    8. M. J. Allday, J. H. Sinclair
      Pages 191-192
    9. C. X. Zhang, M. Tessier, G. Decaussin, J. Daillie, T. Ooka
      Pages 193-194
  5. EBV Proteins and Their Function

    1. Front Matter
      Pages 195-195
    2. G. Miller, J. Countryman, H. Jenson, E. Grogan, L. Gradoville
      Pages 197-206
    3. Thomas B. Sculley, Denis J. Moss, Ron A. Hazelton, John H. Pope
      Pages 207-210

About this book


Since its discovery as the cause of infectious mononucleosis in 1964, the Epstein-Barr virus (EBV) has been etiologically implicated in an increasing number of human diseases. Generally considered the first human oncogenic virus because of a number of studies linking it with Burkitt's lymphoma and nasopharyngeal carcinoma (NPC), as well as its documented oncogenicity in nonhuman primates, EBVhas served as a model for identifying subsequent candidate oncogenic viruses and the stimulus for Evans' revision of the Henle-Koch postulates to accommodate the problems in proving viral oncogenicity in humans. Research on the role of EBV in human cancer was particularly en­ hanced (a) by the pioneering work of Werner and Gertrude Henle, and (b) by the coordinated efforts of the Special Virus Leukemia Program and its successors, the Special Virus Cancer Program and the Virus Cancer Program of the National Cancer Institute (NCI). Initiated by Dr. Frank J. Rauscher, who subsequently became director of the Ncr and is now Vice-President of the American Cancer Society, and expanded by Dr. John B. Moloney, whose contributions to cancer research were honored at this Second International Symposium on EBV and Associated Malignant Diseases, these NCI contract-sup­ ported programs brought together investigators from all over the world to participate in a joint effort to unravel the mystery of EBV behavior and pathogenicity. It was these programs that gave us the opportunity to work with such outstanding people as Professor Yohei Ito, to whom this book is dedicated.


AIDS Antigen blood diseases infection infections interferon leukemia lymphocytes phenotype proteins regulation transplantation vaccine virus

Editors and affiliations

  • P. H. Levine
    • 1
  • D. V. Ablashi
    • 1
  • M. Nonoyama
    • 2
  • G. R. Pearson
    • 3
  • R. Glaser
    • 4
  1. 1.National Cancer InstituteBethesdaUSA
  2. 2.Showa University Research InstituteSt. PetersburgUSA
  3. 3.Georgetown University Medical CenterUSA
  4. 4.The Ohio State UniversityColumbusUSA

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