Relaxing and Contracting Factors

Biological and Clinical Research

  • Paul M. Vanhoutte

Part of the The Endothelium book series (TEEN)

Table of contents

  1. Front Matter
    Pages i-xxv
  2. T. M. Griffith, A. H. Henderson
    Pages 41-64
  3. T. M. Cocks, J. A. Angus, J. H. Campbell, G. R. Campbell
    Pages 107-135
  4. Robert F. Highsmith, David Aichholz, Oliver FitzGerald, Richard Paul, Gabor M. Rubanyi, Kristine Hickey
    Pages 137-158
  5. Eberhard Bassenge, Rudi Busse, Ulrich Pohl
    Pages 189-217
  6. Z. S. Katusic, J. T. Shepherd
    Pages 333-345
  7. J. A. Angus, T. M. Cocks, C. E. Wright, K. Satoh, G. R. Campbell
    Pages 361-387
  8. T. M. Griffith, D. H. Edwards, R. L. Davies, T. J. Harrison, K. T. Evans
    Pages 389-416
  9. Donald S. Houston, Paul M. Vanhoutte
    Pages 425-449
  10. S. Thom, A. Hughes, P. S. Sever
    Pages 511-528
  11. Back Matter
    Pages 529-543

About this book


It is an exciting task to be the editor of the first monograph covering a new area of the biomedical sciences. Since the first report in 1980 by Robert Furchgott and colleagues (see Chapter 1) of the evidence of endothelium-dependent relaxation in isolated arteries, there are ever­ increasing numbers of vascular physiologists and pharmacologists who are scraping away the endothelium to look into its role in cardiovascular con­ trol. And the more one looks, the more one discovers. Not only is the list of substances that can induce endothelium-dependent relaxations im­ pressively long, but these intriguing cells can also secrete vasoconstrictor substances. The ability of the endothelium to modulate the degree of con­ traction of the underlying smooth muscle is an ancestral property of the blood vessel wall, illustrating the logic of nature, since the endothelial cells are located in the best possible strategic location to continuously monitor the properties (chemical or physical) of the blood. And more and more data emerge suggesting that in several cardiovascular diseases per­ turbations in endothelium-dependent responses are one of the early signs of the abnormal process. Thus, the importance of endothelium-dependent responses, triggered by the intellectual curiosity of one of the pioneers of vascular physiology and pharmacology, is now recognized not only by basic scientists, but also by all concerned with the cardiovascular diseases. The purpose of this monograph is to provide them with a reference work, so that they know where to start.


Dilatation Drogen blood vessel cardiovascular cells endothelium hypertension physiology smooth muscle tissue

Editors and affiliations

  • Paul M. Vanhoutte
    • 1
  1. 1.Department of Physiology and BiophysicsMayo Clinic and Mayo FoundationRochesterUSA

Bibliographic information

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