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The alpha-1 Adrenergic Receptors

  • Robert R. RuffoloJr.

Part of the The Receptors book series (REC)

Table of contents

  1. Front Matter
    Pages i-xx
  2. Historical Perspectives

    1. Front Matter
      Pages 1-1
    2. William A. Pettinger, Donald D. Smyth
      Pages 3-16
  3. Characterization of the Receptor and Its Binding Site

  4. Biochemical Mechanism of Receptor Action

    1. Front Matter
      Pages 111-111
    2. Pieter B. M. W. M. Timmermans, Martin J. M. G. Thoolen
      Pages 113-187
    3. James W. Putney Jr
      Pages 189-208
  5. Correlation of Receptor Binding and Function

    1. Front Matter
      Pages 209-209
    2. Robert M. DeMarinis, Margaret Wise, J. Paul Hieble, Robert R. Ruffolo Jr
      Pages 211-265
    3. Kenneth P. Minneman, Peter W. Abel
      Pages 267-324
    4. J. Paul Hieble, William D. Matthews, Robert M. DeMarinis, R. Robert Ruffolo Jr.
      Pages 325-349
    5. E. Szabadi, C. M. Bradshaw
      Pages 405-453
  6. Regulation of Alpha-1 Adrenergic Receptors

    1. Front Matter
      Pages 455-455
    2. Brian B. Hoffman
      Pages 457-474
  7. Agents interacting with alpha-1 Adrenergic Receptors

    1. Front Matter
      Pages 475-475
    2. J. Paul Hieble, Robert R. Ruffolo Jr.
      Pages 477-500
  8. Future Vistas

    1. Front Matter
      Pages 501-501
    2. David B. Bylund, Robert R. Ruffolo Jr.
      Pages 503-507
  9. Back Matter
    Pages 509-543

About this book

Introduction

During the past decade, great strides have been made in our un­ derstanding of the biochemistry and pharmacology of the alpha-l adrenergic receptor. The alpha-l adrenergic receptor plays a key role in biological function. This is evidenced by the fact that the alpha-l adrenergic receptor plays a prominent functional role in most organs of the body and in the key systems responsible for survival of the organism and maintenance of optimum biological activity. This is most apparent in the cardiovascular system, in which alpha-l adrenergic receptors are the single most important receptor involved in the maintenance of blood pressure and circu­ latory function. It is appropriate, therefore, that recent findings related to the pharmacology and biochemistry of the alpha-l adrenergic receptor be compiled, since this subject has not been reviewed in detail in recent years. It is the purpose of this book to present a series of reviews of key experimental findings that shed new light on the alpha-l adrenergic receptor and the manner in which it functions. Classically, most receptors have been characterized based on structure-activity relationships obtained for selective agonists and antagonists interacting with the receptor. Although there are many newer and more sophisticated approaches to receptor char­ acterization, structure-activity relationships still provide impor­ tant information regarding the chemical requirements made by the receptor for its occupation by ligands and its subsequent acti­ vation by those ligands possessing intrinsic efficacy and, there­ fore, agonist activity.

Keywords

Nervous System anatomy biochemistry central nervous system muscle neuroanatomy neurons physiology receptor thermoregulation tissue

Editors and affiliations

  • Robert R. RuffoloJr.
    • 1
  1. 1.Smith Kline & French LaboratoriesSwedelandUSA

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