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Nutrients and Cancer Prevention

  • Kedar N. Prasad
  • Frank L. MeyskensJr.

Part of the Experimental Biology and Medicine book series (EBAM, volume 23)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Mechanisms of Carcinogenesis

    1. Front Matter
      Pages 1-1
  3. Mechanisms of Action of Nutrients in Cancer Prevention

  4. Preclinical Studies in Cancer Prevention and Treatment

  5. Clinical Studies in Cancer Prevention and Treatment

    1. Front Matter
      Pages 239-239
    2. Gabriel Kune, Susan Kune, Barry Field, Lyndsey Watson
      Pages 241-259
    3. Hector F. DeLuca
      Pages 271-288
    4. Leonida Santamaria, Amalia Bianchi Santamaria, Massimo dell’Orti
      Pages 299-317
    5. Maurice M. Black, Reinhard E. Zachrau, Monique F. Katz
      Pages 319-328
  6. Back Matter
    Pages 339-347

About this book

Introduction

During the last 10 years, the role of specific nutrients in cancer prevention and cancer treatment has been the subject of intense basic, preclinical, and clinical research. At present, the major focus of nutri­ tional oncology is on the mechanisms of carcinogenesis and their modification by nutrients and on cancer prevention studies in animals and humans. Some human epidemiological studies have confirmed the hypothesis, developed on animals, that there is an inverse relation­ ship between the intake and/or level of !3-carotene, vitamin A vita­ min E, or vitamin C and the risk of cancer, whereas others have shown no such relationship. This is not unexpected, since the protective effect of individual nutrients may be too small to be detected by epidemiological methodologies in which a single vitamin or mineral is considered as one variable. Conclusive evidence regarding the role of nutrients in human cancer prevention will come from a well­ designed human intervention study using one or more nutrients in a population that has a high risk of developing cancer. The involvement of specific nutrients in the regulation of protooncogene expression has just begun. Also, some of the results of human intervention trials are beginning to yield interesting results. A large number of interna­ tional scientists from various disciplines, including cell biology, mo­ lecular biology, nutritional oncology, epidemiology, and public health, reviewed and discussed their most recent findings. The following topics were emphasized: 1. Mechanisms of carcinogenesis; 2.

Keywords

Public Health Retinol Vitamin Vitamin A Vitamin B6 Vitamin C Vitamin D Vitamin E cancer cancer prevention carotenoids cell biology intervention nutrition prevention

Editors and affiliations

  • Kedar N. Prasad
    • 1
  • Frank L. MeyskensJr.
    • 2
  1. 1.Health Sciences CenterUniversity of ColoradoDenverUSA
  2. 2.Irvine Medical CenterUniversity of CaliforniaOrangeUSA

Bibliographic information

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