The Use of Restricted Significance Tests in Clinical Trials

  • David S. Salsburg

Part of the Springer Series in Statistics book series (SBH)

Table of contents

  1. Front Matter
    Pages i-x
  2. Philosophical and Scientific Problems when Applying Statistical Methods to Clinical Data

    1. Front Matter
      Pages 1-1
    2. David S. Salsburg
      Pages 3-9
    3. David S. Salsburg
      Pages 10-21
    4. David S. Salsburg
      Pages 22-29
    5. David S. Salsburg
      Pages 30-38
    6. David S. Salsburg
      Pages 39-46
  3. Techniques for Applying Restricted Tests to Data from Randomized Controlled Clinical Trials

    1. Front Matter
      Pages 47-47
    2. David S. Salsburg
      Pages 49-59
    3. David S. Salsburg
      Pages 60-77
    4. David S. Salsburg
      Pages 78-88
    5. David S. Salsburg
      Pages 89-96
    6. David S. Salsburg
      Pages 97-103
    7. David S. Salsburg
      Pages 104-114
    8. David S. Salsburg
      Pages 115-125
  4. Back Matter
    Pages 161-174

About this book


The reader will soon find that this is more than a "how-to-do-it" book. It describes a philosophical approach to the use of statistics in the analysis of clinical trials. I have come gradually to the position described here, but I have not come that way alone. This approach is heavily influenced by my reading the papers of R.A. Fisher, F.S. Anscombe, F. Mosteller, and J. Neyman. But the most important influences have been those of my medical colleagues, who had important real-life medical questions that needed to be answered. Statistical methods depend on abstract mathematical theorems and often complicated algorithms on the computer. But these are only a means to an end, because in the end the statistical techniques we apply to clinical studies have to provide useful answers. When I was studying martingales and symbolic logic in graduate school, my wife, Fran, had to be left out of the intellectual excitement. But, as she looked on, she kept asking me how is this knowledge useful. That question, what can you do with this? haunted my studies. When I began working in bio­ statistics, she continued asking me where it was all going, and I had to explain what I was doing in terms of the practical problems that were being ad­ dressed.


Master Patient Index Radiologieinformationssystem Resampling methodology statistics

Authors and affiliations

  • David S. Salsburg
    • 1
  1. 1.Pfizer Research DivisionPfizer, Inc.GrotonUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag New York 1992
  • Publisher Name Springer, New York, NY
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4612-8762-9
  • Online ISBN 978-1-4612-4414-1
  • Series Print ISSN 1431-8776
  • Buy this book on publisher's site