© 1998

G Proteins, Receptors, and Disease

  • Allen M. Spiegel

Part of the Contemporary Endocrinology book series (COE, volume 6)

Table of contents

  1. Front Matter
    Pages i-x
  2. Allen M. Spiegel
    Pages 57-69
  3. Uwe Rudolph, Lutz Birnbaumer
    Pages 71-83
  4. Craig C. Malbon, Patricia Galvin-Parton, Hsien-yu Wang, Christopher M. Moxham
    Pages 85-99
  5. J. Silvio Gutkind, Omar A. Coso, Ningzhi Xu
    Pages 101-117
  6. Kelly E. Mayo, Venita I. DeAlmeida, Kenneth C. Wu
    Pages 217-229
  7. Dongsi Lu, Carrie Haskell-Luevano, Dag Inge Vage, Roger D. Cone
    Pages 231-259
  8. Constantine Tsigos, George P. Chrousos
    Pages 261-269
  9. Walter J. Koch, Robert J. Lefkowitz
    Pages 271-283
  10. Domenico Accili, John Drago, Sara Fuchs
    Pages 285-299
  11. Back Matter
    Pages 321-324

About this book


More than a collection of review articles, G Proteins, Receptors, and Disease summarizes in depth the state of our knowledge today concerning not only how cells communicate via G-protein-coupled signal transduction processes, but also how defects in these proteins and their receptors can cause serious human disease involving many different organ systems. Written by leading investigators, each chapter describes in detail the structure and function of a particular G protein or receptor, outlines possible mutations, and discusses fully the molecular pathogenesis of associated diseases. Diagnostic and therapeutic implications are also discussed when relevant.

In its unique blend of cutting-edge basic science and clinical medicine, G Proteins, Receptors, and Disease offers deep insights into the physiological significance of this key signal transduction pathway, as well as into the molecular basis of diseases ranging from obesity to malignancy. The basic understanding of the complex signal transduction process achieved here provides a firm foundation for future efforts to prevent and cure these diseases.


ACTH Diabetes Diabetes mellitus G proteins Gonadotropin insulin insulin resistance signal transduction

Editors and affiliations

  • Allen M. Spiegel
    • 1
  1. 1.National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of HealthBethesdaUSA

Bibliographic information

  • Book Title G Proteins, Receptors, and Disease
  • Editors Allen M. Spiegel
  • Series Title Contemporary Endocrinology
  • DOI
  • Copyright Information Springer Science+Business Media New York 1998
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-0-89603-430-3
  • Softcover ISBN 978-1-4612-7290-8
  • eBook ISBN 978-1-4612-1802-9
  • Edition Number 1
  • Number of Pages X, 324
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Endocrinology
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Internal Medicine & Dermatology


Winner of one of the Best 1998 Health Sciences Books Awards!
"The book meets the stated objective. . .[of] providing the reader with a complete review of the known molecular and genetic details of the G protein signal cascade and related diseases. . .Each chapter is truly a state-of-the-art description."4 Stars!-Doody's Health Sciences Book Review Journal

"...attractive in its presentation and well illustrated with good quality photographs. . .bibliographies are current and extensive. . .a pleasure to read. . .would complement every medical library and should be highly recommended to clinical and basic scientists."-European Journal of Endocrinology

"G Proteins, Receptors, and Disease is a volume worthy of a place on the bookshelf of anyone with a current interest in endocrine disease and GPCR-targeted approaches to is refreshing to find a book that communicates just how much genomics-based research can accelerate understanding, not just of a discrete area of science, but of human disease."- Nature Medicine