Basic and Clinical Advances

  • Marc R. Blackman
  • Jesse Roth
  • S. Mitchell Harman
  • Jay R. Shapiro
Conference proceedings

Part of the Serono Symposia USA book series (SERONOSYMP)

Table of contents

  1. Front Matter
    Pages i-xix
  2. Overview of Physiology of the GHRH-Somatostatin-GH-IGF-I Axis

    1. Front Matter
      Pages 1-1
    2. Mary Lee Vance, Joseph A. Aloi, Mark L. Hartman, Susan E. Kirk, Michael O. Thorner
      Pages 19-24
    3. P. A. Kelly, J. Finidori, M.-C. Postel-Vinay, M. Edery, L. Goujon, A. Sotiropoulos et al.
      Pages 25-37
    4. Derek LeRoith, Stefan Neuenschwander, Antolii Koval, Charyse Sindler, Charles T. Roberts Jr.
      Pages 38-48
  3. Effects of Recombinant Human GH and/or IGF-I in Catabolic Illness

  4. Contemporary Issues in Growth and Development

    1. Front Matter
      Pages 129-129
    2. Ron G. Rosenfeld, Arlan L. Rosenbloom, Jaime Guevara-Aguirre
      Pages 136-142
    3. Jens S. Christiansen, Jens O. L. Jørgensen, Nina Vahl, Anders Juul, Jørn Müller, Niels E. Skakkebæk
      Pages 169-175
  5. Effects of rhGH and IGF-I on Intermediary and Bone Metabolism

    1. Front Matter
      Pages 177-177
    2. Kenneth C. Copeland, K. Sreekumarun Nair
      Pages 185-194
    3. Robert S. Sherwin, Walter P. Borg, Susan D. Boulware
      Pages 195-203
    4. Robert Marcus
      Pages 217-221
    5. Julie Patterson, Jay R. Shapiro, Marc R. Blackman
      Pages 222-229
  6. Use of GHRH, rhGH, and rhIGF-I in Aging

    1. Front Matter
      Pages 231-231
    2. S. Mitchell Harman, Marc R. Blackman
      Pages 233-240
    3. M. R. Blackman, J. Vittone, E. Corpas, J. Busby-Whitehead, T. Stevens, M. F. Bellantoni et al.
      Pages 257-265
    4. Andrew R. Hoffman, Robert Marcus, Raymond L. Hintz, Gail Butterfield, Janice Thompson, Laura Ghiron et al.
      Pages 266-276
    5. William H. Adler, James E. Nagel, S. Mitchell Harman, Emiliano Corpas, Marc R. Blackman
      Pages 277-290
  7. Back Matter
    Pages 299-321

About these proceedings


Recent research suggests that adult growth hormone (GH) deficiency, whether of pathological or physiological origin, is associated with a dis­ tinct syndrome that includes alterations in body composition, endocrine­ metabolic function, immune competence, and physical and psychosocial well-being. Not surprisingly, substantial investigative effort is currently focused on validating the above hypothesis and on determining whether restoration of a normal GH-IGF-I axis in various states of adult GH deficiency is clinically useful, safe, and cost-beneficial. This book contains the proceedings from the Symposium on GHRH, GH, and IGF-I: Basic and Clinical Advances, held December 9 to 12, 1993, in San Diego, California, and sponsored by Serono Symposia USA, Inc. The conference was meant to highlight selected novel and exciting clinical research developments related to possible therapeutic uses of recombinant human GH and IGF-I, GHRH, GH releasing peptides, and related GH secretagogues. This meeting occurred only one year after a similar Serono symposium that was somewhat more oriented to novel basic science discoveries, thus attesting to the current scientific and clinical interest in this area.


Amino acid Diabetes Diabetes mellitus Lipid bone growth factor insulin-like metabolism physiology signal transduction

Editors and affiliations

  • Marc R. Blackman
    • 1
  • Jesse Roth
    • 2
  • S. Mitchell Harman
    • 3
  • Jay R. Shapiro
    • 2
  1. 1.Division of Endocrinology and Metabolism Department of MedicineJohns Hopkins University School of MedicineBaltimoreUSA
  2. 2.Division of Geriatric Medicine and Gerontology Department of MedicineJohns Hopkins University School of MedicineBaltimoreUSA
  3. 3.Gerontology Research CenterNational Institute on Aging, National Institutes of HealthBaltimoreUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag New York, Inc. 1995
  • Publisher Name Springer, New York, NY
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4612-6908-3
  • Online ISBN 978-1-4612-0807-5
  • Buy this book on publisher's site
Industry Sectors
Consumer Packaged Goods