Cystic Fibrosis

Infection, Immunopathology, and Host Response

  • Richard B. Moss

Part of the Allergy and Immunology book series (ALIM, volume 1)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Richard B. Moss
    Pages v-ix
  3. Jeffrey J. Wine
    Pages 1-28
  4. Ricardo U. Sorensen, Robert L. Waller, Jeffrey D. Klinger
    Pages 47-74
  5. David P. Greenberg, Harris R. Stutman
    Pages 75-86
  6. Alan P. Knutsen, Raymond G. Slavin
    Pages 103-118
  7. Victoria B. van King
    Pages 143-157
  8. Robert S. Tepper, Howard Eigen
    Pages 159-168
  9. Michael Spino
    Pages 169-210
  10. Richard B. Moss
    Pages 211-229
  11. Norman Lewiston, Vaughn Starnes, James Theodore
    Pages 231-247
  12. Back Matter
    Pages 249-251

About this book


This work is concerned with Cystic Fibrosis (CF), the most common fatal genetic disease in the Caucasian population. The decade of the 1980s was one of spectacular progress in understanding the genetic and molecu­ lar basis of CF. The research breakthroughs of the decade began with the first fundamental insights, published in 1981-1983, into the basic cellular pathophysiology of CF with demonstrations of altered ion transport in spe­ cialized exocrine epithelial tissues (1-3). Research progress shifted into a triumph of "reverse genetics," using restriction-fragment-Iength polymor­ phism DNA technology (4), with the localization of the CF gene to a region of chromosome 7 (5-7). Understanding, accelerated by an explOSion of in vitro methodologies for epithelial cell culture and transformation, allowed and physiological studies (8-11); these focused, controlled biochemical with increasing precision, on the molecular pathology of distal steps in the regulatory pathways for epithelial ion transport (12-19). Finally, the "end of the beginning" occurred in late 1989 with one of the great achievements of molecular genetics, the isolation and cloning of the CF gene (20). As a result, we now have a CF gene product, the cystic fibrosis transmembrane regulator (CFfR), possessing predicted amino acid sequence, suggested tertiary structure, and possible transmembrane transport function (21). These amazing developments have set the stage for the next round of advances, which surely will include: 1.


allergy bacteria cell biology infection infections infectious disease inflammation pathology pseudomonas transplantation

Editors and affiliations

  • Richard B. Moss
    • 1
  1. 1.Stanford University School of MedicinePalo AltoUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 1990
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4612-6778-2
  • Online ISBN 978-1-4612-0475-6
  • Buy this book on publisher's site