© 1991

Neoplastic Transformation in Human Cell Culture

Mechanisms of Carcinogenesis

  • Johng S. Rhim
  • Anatoly Dritschilo

Part of the Experimental Biology and Medicine book series (EBAM, volume 25)

Table of contents

  1. Front Matter
    Pages i-xxxi
  2. Preneoplastic Events

    1. Front Matter
      Pages 1-1
    2. B. Lynn Allen-Hoffmann, Nader Sheibani, Jill S. Hatfield, Johng S. Rhim
      Pages 25-34
    3. William E. Fahl, William H. Brondyk, Hua-Ming Jin, Craig W. Stevens, Carsten-Peter Carstens, Gregory C. Kujoth et al.
      Pages 35-46
    4. C. Chandra Kumar, Cecile Chang, Johng Rhim
      Pages 47-56
    5. S. Beninati, S. C. Park, M. Piacentini, J. S. Rhim, S. I. Chung
      Pages 57-64
  3. Radiation Transformation and Oncogenes

    1. Front Matter
      Pages 65-65
    2. Dennis E. Hallahan, Matthew L. Sherman, Donald Kufe, Ralph R. Weichselbaum
      Pages 81-92
    3. P. Thraves, S. Reynolds, Z. Salehi, W. K. Kim, J. H. Yang, J. S. Rhim et al.
      Pages 93-101
    4. T. C. Yang, M. R. Stampfer, J. S. Rhim
      Pages 103-111
    5. James C. Willey, Jim Greene, Alberec Bressoud, Peter Cerutti, Tom Hei, Nancy Wang et al.
      Pages 113-117
    6. S. Srivastava, Z. Zou, K. Pirollo, D. Tong, V. Sykes, K. Devadas et al.
      Pages 125-134
    7. M. Nagarajan, M. Bowman, L. Rigby, J. S. Rhim, S. Sukumar
      Pages 135-139
  4. Viral Transformation and Oncogenes

    1. Front Matter
      Pages 141-141
    2. Jonathan A. Rhim, Jonathan Vogel, Chang-Min Kim, Gilbert Jay, Johng S. Rhim
      Pages 143-152

About this book


The role of carcinogenic agents in the deveolopment of human cancers is now being defined using a variety of human cells as experi­ mental model systems. A workshop on "neoplastic transformation in human cell systems in vitro: mechanisms of carcinogenesis" was held at the Georgetown University Medical Center, Washington, DC, on April 25-26, 1991. The aims of the workshop were to present the state-of-the­ art in the transformation of human cells in culture, as well as to provide insight into the molecular and cellular changes involved in the conver­ sion of normal cells to a neoplastic state of growth. The following topics were closely related to the theme of the workshops: 1. Derivation of in vitro model systems (epithelial, fibroblastic, and hematopoietic). 2. Factors modulating cellular transformation. 3. Usefulness of defined in vitro model systems for viral, chemical, and radiation carcinogenesis. 4. Multistep nature of human cell carcinogenesis. 5. Role of activated and suppressor oncogenes in neoplastic trans­ formation. The workshop was organized by J. S. Rhim and A. Dritschilo (cochairmen), G. Jay, J. little, M. McCormick, R Tennant, and R R Weischelbaum. There were 32 speakers, 30 poster presentations, and about 190 participants.


Activation DNA aging cancer cancer research carcinogenesis carcinoma cell cell culture mutation oncogene oncogenes pathogenesis regulation tumor

Editors and affiliations

  • Johng S. Rhim
    • 1
  • Anatoly Dritschilo
    • 2
  1. 1.Laboratory of Cellular and Molecular BiologyNational Cancer InstituteBethesdaUSA
  2. 2.Department of Radiation MedicineGeorgetown University Medical CenterUSA

Bibliographic information

  • Book Title Neoplastic Transformation in Human Cell Culture
  • Book Subtitle Mechanisms of Carcinogenesis
  • Authors Johng S. Rhim
    Anatoly Dritschilo
  • Series Title Experimental Biology and Medicine
  • DOI
  • Copyright Information Springer Science+Business Media New York 1991
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-0-89603-227-9
  • Softcover ISBN 978-1-4612-6750-8
  • eBook ISBN 978-1-4612-0411-4
  • Edition Number 1
  • Number of Pages XXXI, 396
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Pathology
  • Buy this book on publisher's site
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...should be a part of any departmental library serving virologists, cell biologists, pathologists, and other scientists interested in malignant cell growth.-Quarterly Review of Biology