Neoplastic Transformation in Human Cell Culture

Mechanisms of Carcinogenesis

  • Johng S. Rhim
  • Anatoly Dritschilo

Part of the Experimental Biology and Medicine book series (EBAM, volume 25)

Table of contents

  1. Front Matter
    Pages i-xxxi
  2. Preneoplastic Events

    1. Front Matter
      Pages 1-1
    2. B. Lynn Allen-Hoffmann, Nader Sheibani, Jill S. Hatfield, Johng S. Rhim
      Pages 25-34
    3. William E. Fahl, William H. Brondyk, Hua-Ming Jin, Craig W. Stevens, Carsten-Peter Carstens, Gregory C. Kujoth et al.
      Pages 35-46
    4. C. Chandra Kumar, Cecile Chang, Johng Rhim
      Pages 47-56
    5. S. Beninati, S. C. Park, M. Piacentini, J. S. Rhim, S. I. Chung
      Pages 57-64
  3. Radiation Transformation and Oncogenes

    1. Front Matter
      Pages 65-65
    2. Dennis E. Hallahan, Matthew L. Sherman, Donald Kufe, Ralph R. Weichselbaum
      Pages 81-92
    3. P. Thraves, S. Reynolds, Z. Salehi, W. K. Kim, J. H. Yang, J. S. Rhim et al.
      Pages 93-101
    4. T. C. Yang, M. R. Stampfer, J. S. Rhim
      Pages 103-111
    5. James C. Willey, Jim Greene, Alberec Bressoud, Peter Cerutti, Tom Hei, Nancy Wang et al.
      Pages 113-117
    6. S. Srivastava, Z. Zou, K. Pirollo, D. Tong, V. Sykes, K. Devadas et al.
      Pages 125-134
    7. M. Nagarajan, M. Bowman, L. Rigby, J. S. Rhim, S. Sukumar
      Pages 135-139
  4. Viral Transformation and Oncogenes

    1. Front Matter
      Pages 141-141
    2. Jonathan A. Rhim, Jonathan Vogel, Chang-Min Kim, Gilbert Jay, Johng S. Rhim
      Pages 143-152
    3. M. Conrad, J. Yankaskas, R. Boucher, R. Schlegel
      Pages 163-167
    4. Vimla Band, Ruth Sager
      Pages 169-178
    5. L. Braun, M. Dürst, R. Mikumo, A. Blaschke, A. Crowley, K. Rowader
      Pages 179-189
    6. Elliott Kieff, Fred Wang, Mark Birkenbach, Jeffrey Cohen, Jeffrey Sample, Blake Tomkinson et al.
      Pages 191-201
    7. D. Carbone, R. Maneckjee, D. D’Amico, S. Bader, S. Bodner, I. Chiba et al.
      Pages 213-221
  5. Multistep Models

    1. Front Matter
      Pages 233-233
    2. Martha R. Stampfer, Paul Yaswen, Gordon Parry, Junko Hosoda
      Pages 259-267
    3. C. A. Reznikoff, C. Kao, E. A. Bookland, A. J. Klingelhutz, C. I. Pratt, S. Q. Wu et al.
      Pages 269-280
    4. A. C. Williams, A. Manning, S. J. Harper, C. Paraskeva
      Pages 281-290
    5. A. Haugen, L. Maehle, D. Ryberg, I. L. Hansteen
      Pages 291-296
    6. Gary D. Stoner, Bret A. Light, Curtis C. Harris
      Pages 297-305
    7. John F. Lechner, Duane T. Smoot, Andrea M. A. Pfeifer, Katharine H. Cole, Ainsley Weston, John D. Groopman et al.
      Pages 307-321
    8. Masayoshi Namba, Yoshio Kano, Li-yan Bai, Koichiro Mihara, Masahiro Miyazaki
      Pages 323-332
    9. D. P. Chopra, A. P. Joiakim, B. Retherford, P. A. Mathieu, J. S. Rhim
      Pages 333-341
    10. J. L. Rutkowski, J. S. Rhim, K. W. C. Peden, G. I. Tennekoon
      Pages 343-346
    11. J. Justin McCormick, Veronica M. Maher
      Pages 347-357
    12. James G. Rheinwald, Ross Tubo, Beatrice Zenzie, Therese O’Connell, Anita Terpstra
      Pages 359-366
    13. Zahra Salehi, Susan Ramos, Gary Pearson, Mira Jung, Anatoly Dritschilo, Francis G. Kern
      Pages 377-386
  6. Back Matter
    Pages 387-396

About this book


The role of carcinogenic agents in the deveolopment of human cancers is now being defined using a variety of human cells as experi­ mental model systems. A workshop on "neoplastic transformation in human cell systems in vitro: mechanisms of carcinogenesis" was held at the Georgetown University Medical Center, Washington, DC, on April 25-26, 1991. The aims of the workshop were to present the state-of-the­ art in the transformation of human cells in culture, as well as to provide insight into the molecular and cellular changes involved in the conver­ sion of normal cells to a neoplastic state of growth. The following topics were closely related to the theme of the workshops: 1. Derivation of in vitro model systems (epithelial, fibroblastic, and hematopoietic). 2. Factors modulating cellular transformation. 3. Usefulness of defined in vitro model systems for viral, chemical, and radiation carcinogenesis. 4. Multistep nature of human cell carcinogenesis. 5. Role of activated and suppressor oncogenes in neoplastic trans­ formation. The workshop was organized by J. S. Rhim and A. Dritschilo (cochairmen), G. Jay, J. little, M. McCormick, R Tennant, and R R Weischelbaum. There were 32 speakers, 30 poster presentations, and about 190 participants.


Activation DNA aging cancer cancer research carcinogenesis carcinoma cell cell culture mutation oncogene oncogenes pathogenesis regulation tumor

Editors and affiliations

  • Johng S. Rhim
    • 1
  • Anatoly Dritschilo
    • 2
  1. 1.Laboratory of Cellular and Molecular BiologyNational Cancer InstituteBethesdaUSA
  2. 2.Department of Radiation MedicineGeorgetown University Medical CenterUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 1991
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4612-6750-8
  • Online ISBN 978-1-4612-0411-4
  • Buy this book on publisher's site
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