Molecular Biology of Diabetes

1. Front Matter

   Pages i-xiii

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2. Molecular Mechanisms of Autoimmunity and Genetics of Diabetes

   1. Front Matter

      Pages N1-N1

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   2. Molecular Targets of the Autoimmunity of Type I Diabetes

      • Massimo Pietropaolo, George S. Eisenbarth

      Pages 1-33

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   3. Murine Transgenic Models of IDDM

      • Danling Gu, Nora Sarvetnick

      Pages 35-47

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   4. Pancreatic Islet Transplantation

      • Ronald G. Gill

      Pages 49-67

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   5. Pathogenesis of Autoimmune Diabetes

      • Filippo Calcinaro, Dale R. Wegmann, Kevin J. Lafferty

      Pages 69-90

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3. Molecular and Cellular Aspects of Insulin Synthesis and Secretion

   1. Front Matter

      Pages N2-N2

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   2. Insulin Gene Structure and Regulation

      • Michael S. German

      Pages 91-117

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   3. Molecular Engineering of Glucose-Regulated Insulin Secretion

      • Christopher B. Newgard, Sarah Ferber, Christian Quaade, John H. Johnson, Steven D. Hughes

      Pages 119-154

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   4. Glucokinase Gene Expression and Regulation

      • Mark A. Magnuson, Kevin D. Niswender, Cathleen C. Pettepher

      Pages 155-174

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   5. Fundamentals of Fuel Sensing and Intermediary Metabolism in Pancreatic A-and B-Cells

      • Guizhu Li, Prabakaran Kesavan, Habiba Najafi, Lijun Wang, Peter Ronner, Donna Berner et al.

      Pages 175-193

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   6. Glucose Toxicity and the Insulin Gene

      • R. Paul Robertson, L. Karl Olson, J. Bruce Redmon, Hui-Jian Zhang, Howard C. Towle

      Pages 195-212

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   7. Proinsulin-Processing Endopeptidases

      • Deborah L. Bennett, John C. Hutton

      Pages 213-248

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   8. GTP and Its Binding Proteins in the Regulation of Insulin Exocytosis

      • Anjaneyulu Kowluru, Stewart A. Metz

      Pages 249-283

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   9. β-Cell Receptors

      • Joseph S. Dillon, Ming Lu, Michael B. Wheeler, Aubrey E. Boyd III

      Pages 285-301

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   10. Molecular Biology of the Ion Channels in the Pancreatic β-Cell

       • Illani Atwater, Manuel Kukuljan, Elia Martha Pérez-Armendariz

       Pages 303-332

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   11. Molecular Biology of Gap Junction Proteins

       • Paolo Meda

       Pages 333-356

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   12. The GIuco-Incretin Hormone Glucagon-Like Peptide-1 and Its β-Cell Receptor

       • Bernard Thorens

       Pages 357-379

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   13. Islet Amyloid Polypeptide (IAPP) and Insulin Secretion

       • Peter C. Butler, Norman L. Eberhardt, Timothy D. O’Brien

       Pages 381-398

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4. Back Matter

   Pages 399-404

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In a rapidly evolving and extremely important area of medical science, it is often difficult for the student, teacher, and researcher to keep abreast of all the important advances. The purpose of Molecular Biology ofDiabetes, Parts I and II is to bring to these individuals the latest knowledge of diabetes-related research in a comprehensive, yet concise manner. To this end, we have assembled chapters, written by most of the world's experts in the field, that we believe compre­ hensively survey and synthesize a coherent understanding of the subject. Studies of the etiology of type I and type II diabetes are extremely exciting and essential, since we hope to one day prevent the disease using gene therapy. These aspects are covered in Molecular Biology of Diabetes: I. Autoimmunity and Genetics; Insulin Synthesis and Secretion. In type II diabetes, an abnormality in pancreatic secretion exists concomitantly with peripheral insulin resistance. This abnor­ mality of insulin secretion is believed to be related to a defect(s) in glucose sensing. Uncoupling of glucose sensing from insulin secre­ tion may be the crucial step in the pathogenesis of noninsulin-depen­ dent diabetes. In this volume, we have invited authors to describe their studies on all known factors affecting ~-cell function, including autoimmunity and genetics of diabetes, as well as molecular mecha­ nisms of insulin synthesis and secretion. In the last few years, the most rapidly advancing area of research in diabetes has been, in fact, related to insulin action.

• Diabetes
• G proteins
• Insulin
• Insulin Secretion
• gene expression
• genes
• molecular biology
• molecular mechanisms
• signal transduction

This is an essential book for a medical library to have, and it is a welcome addition to the library of investigators in the field. Specialists in diabetes will also find this book very useful. - Kevan Herold, MD for Doody's Health Science Book Review Journal

• University of Colorado Health Sciences Center, Denver, USA

  Boris Draznin

• National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, USA

  Derek LeRoith

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