Early Pregnancy Loss

Mechanisms and Treatment

  • Frank Sharp
  • Richard W. Beard

Table of contents

  1. Front Matter
    Pages i-xviii
  2. The Clinical Problem

    1. Front Matter
      Pages 1-1
    2. E. Alberman
      Pages 9-17
    3. R. W. Beard
      Pages 19-22
    4. R. W. Beard
      Pages 39-42
    5. R. W. Beard
      Pages 61-65
  3. Experimental Models of Early Pregnancy Failure

  4. Studies of the Normal and Failing Placenta in Early Pregnancy

    1. Front Matter
      Pages 147-147
    2. W. B. Robertson
      Pages 159-160
    3. Y. W. Loke
      Pages 161-168
    4. W. B. Robertson
      Pages 169-169
    5. J. N. Bulmer, A. Ritson
      Pages 171-180
    6. W. B. Robertson
      Pages 181-182
    7. J. G. Grudzinskas, I. Stabile, S. Campbell
      Pages 183-190
    8. W. B. Robertson
      Pages 191-192
    9. W. B. Robertson
      Pages 199-199
  5. Factors which Maintain Pregnancy at and Immediately After Implantation

  6. Genetic Causes of Early Pregnancy Failure

    1. Front Matter
      Pages 267-267
    2. J. Klein, V. Vincek, M. Kasahara, F. Figueroa
      Pages 269-274
    3. T J Gill
      Pages 275-276
    4. T. J. Gill III, H. N. Ho, A. Kanbour, T. A. Macpherson, D. N. Misra, H. W. Kunz
      Pages 277-286
    5. T. J. Gill
      Pages 287-291
    6. T. J. Gill
      Pages 305-308
    7. T. J. Gill
      Pages 317-320
  7. Techniques, Treatment Criteria and Outcome of Immunotherapy in Recurrent Abortion

    1. Front Matter
      Pages 321-321
    2. J. Mowbray
      Pages 323-323

About this book


The first few months of any pregnancy are of supreme importance to the success of that pregnancy. This statement is so obvious as to be almost a platitude, yet it must be said that no aspect of pregnancy has been more neglected in the human than the first three months. Little is known of the morphological changes that occur at that time and our knowledge of the mechanisms that control this vital stage of pregnancy is almost non-existent. The explanation for this neglect of what is an obvious area for study is the difficulty of obtaining normal material. It is rare to have material to study from a healthy first trimester pregnancy and the study by Hertig and Rock!l) of early conception found by chance in hysterectomy speci­ mens must be unique. The information that we do have about early pregnancy is mostly gained from animal studies or single miscarriages in humans. Chromosomal defects are common but are not an explanation for the majority of recurrent miscarriages. Obstetricians have hypothesised many causes for this condition and have deve­ loped numerous metQods for treating it, but the studies have been poorly con­ trolled so that our understanding of the cause(s) has not advanced. Treatment of women with a history of recurrent miscarriage by paternal leuco­ cyte infusion (immunotherapy) may be yet another form of treatment that is hailed as a new advance only to be rejected when subject to rigorous testing.


immunotherapy placenta pregnancy

Editors and affiliations

  • Frank Sharp
    • 1
  • Richard W. Beard
    • 2
  1. 1.Department of Obstetrics and GynaecologyNorthern General HospitalSheffieldUK
  2. 2.Department of Obstetrics and GynaecologySt Mary’s HospitalLondonUK

Bibliographic information

Industry Sectors
Health & Hospitals