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© 2011

Kainate Receptors

Novel Signaling Insights

  • Antonio Rodríguez-Moreno
  • Talvinder S. Sihra
  • Examines the functional actions of the kainate-type glutamate receptors (KARs)

  • Provides new insights into how KARs inhibit the slow after-hyperpolarisation current

  • Gives insights into KAR interaction with intracellular binding partners

Book

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 717)

Table of contents

About this book

Introduction

This volume critically examines the functional actions of the kainate‑type glutamate receptors (KARs). Following on from the larger body of work on the NMDA‑ and AMPA-type ionotropic glutamate receptors (GluRs), studies with KARs have consistently thrown up exceptions to general rules about synaptic modulation. Contributors herein provide an insight to the idiosyncracies that now almost typify the KAR field. The fascinating insights provided in this volume serve to encourage searching mechanistic questions.

Keywords

KAR Kainate Receptor Rodríguez‑Moreno Signaling

Editors and affiliations

  • Antonio Rodríguez-Moreno
    • 1
  • Talvinder S. Sihra
    • 2
  1. 1.Departamento de Fisiología, Anatomía y Biología CelularUniversidad Pablo de OlavideSevillaSpain
  2. 2.Department of Neuroscience, Physiology and PharmacologyUniversity College LondonLondonUK

About the editors

ANTO NIO RODRIGUEZ‑MORENO is Associate Professor and Head of the Cellular Neuroscience and Plasticity Laboratory at the University Pablo de Olavide, in Seville, Spain. His main research interests include the study of the mechanisms of synaptic plasticity in cortex and hippocampus and the physiology of glutamate receptors of the NMDA and kainate type. He is a member of the Federation of European Neuroscience Societies (FENS) and the Society for Neuroscience (SFN). Following a degree in Biological Sciences at the University of Seville, Dr. Rodriguez‑Moreno received his PhD degree in Neurobiology and Molecular Biology from Cajal Institute and the University Automous of Madrid in Madrid, Spain. During a first postdoc at the University Pablo de Olavide, in Seville (Spain) he studied the mechanisms of learning and memory in awake animals. This was followed by a postdoctoral stay at University College London (UK) where he investigated the actions of kainate receptors using synaptosomes and brain slices. During a third postdoc at University of Oxford, he started to study the mechanisms of brain plasticity processes.

 

 

TAL VINDER S. SIHRA is a Reader in Cellular and Molecular Neuroscience, and Teaching Lead in the Department of Neuroscience, Physiology and Pharmacology at University College London (UCL) UK. His main research interests are in the elucidation and characterisation of presynaptic receptors and downstream signaling pathways involved in the modulation of neurotransmitter release. Pursuant to an undergraduate degree in Biochemistry and Physiology from the University of Sheffield, UK, he completed his PhD (Biochemistry) in 1985 at the University of Dundee, Scotland, where he initiated his studies looking at the mechanisms underlying amino acid neurotransmitter release. He extended these studies at the Rockefeller University, New York, USA, in the laboratory of Professor Paul Greengard, Nobel Laureate in Medicine (2000), looking at the role of protein phosphorylation in presynaptic function and plasticity. In 1993, he obtained a faculty position at the University of London (Royal Free Hospital School of Medicine), and continued thereafter at UCL. Dr. Sihra is a member of the Biochemical Society (UK) and currently on the Signalling theme panel for the Society. He is a member of the Society of Neuroscience and former editor of the British Journal of Pharmacology.

TAL VINDER S. SIHRA is a Reader in Cellular and Molecular Neuroscience, and Teaching Lead in the Department of Neuroscience, Physiology and Pharmacology at University College London (UCL) UK. His main research interests are in the elucidation and characterisation of presynaptic receptors and downstream signaling pathways involved in the modulation of neurotransmitter release. Pursuant to an undergraduate degree in Biochemistry and Physiology from the University of Sheffield, UK, he completed his PhD (Biochemistry) in 1985 at the University of Dundee, Scotland, where he initiated his studies looking at the mechanisms underlying amino acid neurotransmitter release. He extended these studies at the Rockefeller University, New York, USA, in the laboratory of Professor Paul Greengard, Nobel Laureate in Medicine (2000), looking at the role of protein phosphorylation in presynaptic function and plasticity. In 1993, he obtained a faculty position at the University of London (Royal Free Hospital School of Medicine), and continued thereafter at UCL. Dr. Sihra is a member of the Biochemical Society (UK) and currently on the Signalling theme panel for the Society. He is a member of the Society of Neuroscience and former editor of the British Journal of Pharmacology.

TAL VINDER S. SIHRA is a Reader in Cellular and Molecular Neuroscience, and Teaching Lead in the Department of Neuroscience, Physiology and Pharmacology at University College London (UCL) UK. His main research interests are in the elucidation and characterisation of presynaptic receptors and downstream signaling pathways involved in the modulation of neurotransmitter release. Pursuant to an undergraduate degree in Biochemistry and Physiology from the University of Sheffield, UK, he completed his PhD (Biochemistry) in 1985 at the University of Dundee, Scotland, where he initiated his studies looking at the mechanisms underlying amino acid neurotransmitter release. He extended these studies at the Rockefeller University, New York, USA, in the laboratory of Professor Paul Greengard, Nobel Laureate in Medicine (2000), looking at the role of protein phosphorylation in presynaptic function and plasticity. In 1993, he obtained a faculty position at the University of London (Royal Free Hospital School of Medicine), and continued thereafter at UCL. Dr. Sihra is a member of the Biochemical Society (UK) and currently on the Signalling theme panel for the Society. He is a member of the Society of Neuroscience and former editor of the British Journal of Pharmacology.

Bibliographic information

  • Book Title Kainate Receptors
  • Book Subtitle Novel Signaling Insights
  • Editors Antonio Rodriguez-Moreno
    Talvinder S. Sihra
  • Series Title Advances in Experimental Medicine and Biology
  • DOI https://doi.org/10.1007/978-1-4419-9557-5
  • Copyright Information Landes Bioscience and Springer Science+Business Media, LLC 2011
  • Publisher Name Springer, Boston, MA
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-1-4419-9556-8
  • eBook ISBN 978-1-4419-9557-5
  • Series ISSN 0065-2598
  • Edition Number 1
  • Number of Pages XX, 131
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Biomedicine, general
    Molecular Medicine
  • Buy this book on publisher's site
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