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Advances in Male Mediated Developmental Toxicity

  • Bernard Robaire
  • Barbara F. Hales
Book

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 518)

Table of contents

  1. Front Matter
    Pages i-xxvii
    PDF

  2. Gender-Specificity of Gamete Susceptibilities to Exposures

    1. Female-specific reproductive toxicites following preconception exposure to xenobiotics
      Jack B. Bishop
      Pages 1-9
    2. Overview of male-mediated developmental toxicity
      Diana Anderson
      Pages 11-24

  3. Exposures and Effects: Occupational and Environmental

    1. Epidemiologic evidence on biological and environmental male factors in embryonic loss
      Jens Peter Bonde, Henrik I. Hjøllund, Tine B. Henriksen, Tina K. Jensen, Marcello Spanò, Henrik Kolstad et al.
      Pages 25-35
    2. Mechanisms of Male Mediated Developmental Toxicity Induced by Lead
      Ellen K. Silbergeld, Betzabet Quintanilla-Vega, Robin E. Gandley
      Pages 37-48
    3. Paternal Exposure to Known Mutagens and Health of the Offspring: Ionizing Radiation and Tobacco Smoke
      David A. Savitz
      Pages 49-57
    4. Fish (Fluorescence in situ hybridization) to Detect Effects of Smoking, Caffeine, and Alcohol on Human Sperm Chromosomes
      Wendie A. Robbins
      Pages 59-72

  4. Markers of Sperm Damage and Germ Line Genotoxicity

    1. Sperm Nuclear DNA Damage in the Human
      Denny Sakkas, Gian Carlo Manicardi, Davide Bizzaro
      Pages 73-84
    2. The Human Spermatozoon — Not Waving but Drowning
      R. John Aitken, Dennis Sawyer
      Pages 85-98
    3. Model Systems for Studying Germ Cell Mutagens: From Flies to Mammals
      Ekkehart W. Vogel, Madeleine J. M. Nivard
      Pages 99-114
    4. Germline Mutation Induction at Mouse and Human Tandem Repeat DNA Loci
      Yuri E. Dubrova
      Pages 115-129
    5. Paint/DAPI Analysis of Mouse Zygotes to Detect Paternally Transmitted Chromosomal Aberrations
      Francesco Marchetti, Andrew J. Wyrobek
      Pages 131-145

  5. Exposures and Effects: Causes of Cancer and Consequences of Treatment

    1. Paternal Occupation and Childhood Cancer
      Andrew F. Olshan, Edwin van Wijngaarden
      Pages 147-161
    2. Radiation and Malformations in a Murine Model
      Wolfgang-U. Müller
      Pages 163-168
    3. Mechanisms of Action of Cyclophosphamide as a Male-Mediated Developmental Toxicant
      Bernard Robaire, Barbara F. Hales
      Pages 169-180
    4. Chromosome Abnormalities in Human Sperm
      Renée H. Martin
      Pages 181-188

  6. Pregnancy Outcome

    1. Distinguishing between Fertilization Failure and Early Pregnancy Loss when Identifying Male-Mediated Adverse Pregnancy Outcomes
      Sally D. Perreault
      Pages 189-198
    2. ICSI, Male Pronuclear Remodeling and Cell Cycle Checkpoints
      Laura Hewitson, Calvin R. Simerly, Gerald Schatten
      Pages 199-210
    3. Increased Incidence of Malformations in the Offspring of Male Mice Prenatally Exposed to Synthetic Estrogens
      Tetsuji Nagao, Nao Kagawa, Madoka Nakagomi, Kazuo Fujikawa
      Pages 211-217

  7. Strategies for Prevention

    1. Implications of Research in Male-Mediated Developmental Toxicity to Clinical Counsellors, Regulators, and Occupational Safety Officers
      J. M. Friedman
      Pages 219-226
    2. Restoration of Spermatogenesis After Exposure to Toxicants: Genetic Implications
      Marvin L. Meistrich, Gene Wilson, Gunapala Shetty, Gladis A. Shuttlesworth
      Pages 227-237

  8. Future Directions

    1. Epigenetics: Role of Germ Cell Imprinting
      Marisa S. Bartolomei
      Pages 239-245
    2. Efficiency and Safety of Animal Cloning
      Ryuzo Yanagimachi
      Pages 247-252

  9. Workshop Reports

    1. Integrating New Tests of Sperm Genetic Integrity into Semen Analysis: Breakout Group Discussion
      Sally D. Perreault, R. John Aitken, H. W. Gordon Baker, Donald P. Evenson, Gabor Huszar, D. Stewart Irvine et al.
      Pages 253-268
    2. Risk Assessment
      Andrew F. Olshan, Gary Kimmel, Donald Mattison
      Pages 269-270
    3. Study Designs for the Assessment of Male-Mediated Developmental Toxicity
      Barbara F. Hales, Daniel G. Cyr
      Pages 271-277
    4. Translational Research in Male Mediated Developmental Toxicity
      Jacquetta M. Trasler
      Pages 279-284
  10. Back Matter
    Pages 285-300
    PDF

About this book

Keywords

Chromosom DNA FISH Imprinting Prevention Translation genetics hybridization

Editors and affiliations

  • Bernard Robaire
    • 1
  • Barbara F. Hales
    • 1
  1. 1.McGill UniversityMontrealCanada

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4419-9190-4
  • Copyright Information Kluwer Academic/Plenum Publishers, New York 2003
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-4829-0
  • Online ISBN 978-1-4419-9190-4
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site
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