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Membrane Transporter Diseases

  • Stefan Bröer
  • Carsten A. Wagner

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Introduction to membrane transport

    1. Stefan Bröer, Carsten A. Wagner
      Pages 1-25
  3. Renal Transport of Electrolytes and Acid-Base Equivalents

  4. Transporters of Trace elements and Biominerals

    1. Front Matter
      Pages 81-81
    2. Carsten A. Wagner
      Pages 83-92
    3. Michael D. Garrick, Laura M. Garrick
      Pages 107-122
    4. Antonello Pietrangelo
      Pages 123-131
  5. Transporters of Energy Metabolites and Building Blocks

    1. Front Matter
      Pages 133-133
    2. Stefan Bröer
      Pages 135-145
    3. Keiko Kobayashi, Takeyori Saheki
      Pages 147-160
    4. Nicola Longo, Cristina Amat Di San Filippo, Marzia Pasquali
      Pages 161-174
    5. Janice Yang Chou, Brian C. Mansfield
      Pages 191-205
    6. Josep Chillarón, Joan Bertran, Manuel Palacín
      Pages 207-231
  6. ABC Transporters

    1. Front Matter
      Pages 249-249
    2. Stefan Bröer, Wolfgang E. Kaminski, Gerd Schmitz
      Pages 251-261
    3. Morimasa Wada, Takeshi Uchiumi, Michihiko Kuwano
      Pages 263-289
    4. Gerd Schmitz, Wolfgang E. Kaminski
      Pages 291-299
  7. Transporters Involved in Signal Transduction

    1. Front Matter
      Pages 339-339
    2. Stefan Bröer
      Pages 341-348
    3. Rajini Rao, Giuseppe Inesi
      Pages 365-381
  8. Back Matter
    Pages 383-390

About this book

Introduction

Every cell and organism faces the problem of spaces, made up of the two leaflets of the lipid generating a confined space in which metabolic bilayer. The importance of traffic and signaling across membranes is reflected by the estimate and anabolic reactions take place and at the same time allowing entry and exit of metabo­ that 20% of all genes in the human genome encode membrane proteins. A failure of any of lites, ions, proteins, and signals across its bor­ der. Evolution has solved the problem by these proteins may have dramatic con se­ generating lipid membranes that contain trans­ quences for ceH function. In recent years much porters, ion channels, and receptors. In eukary­ attention has been paid to diseases resulting otic cells, this problem is exacerbated by the from nonfunctional ion channels ("chan­ presence of multiple organelles, which are con­ nelopathies"). Not surprisingly, many of these fined spaces in their own right. Even the lipid diseases affect the excitability of cells. membrane consists of two relatively separate Transporter diseases (perhaps coined "carrier vi PREFACE diseases") are more related to metabolic dis­ Each chapter is concluded by a summary, and eases, Transporters are frequently found at the most chapters also contain an overview of the beginning or the end of metabolic pathways clinical features of a particular transporter and as a result can have similar effects to disease. a missing enzyme.

Keywords

ATP Amino acid Aspartat Glutamat Glycogen Oxidation dopamine pathophysiology physiology

Editors and affiliations

  • Stefan Bröer
    • 1
  • Carsten A. Wagner
    • 2
  1. 1.Australian National UniversityCanberraAustralia
  2. 2.University of ZurichZurichSwitzerland

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4419-9023-5
  • Copyright Information Kluwer Academic / Plenum Publishers, New York 2003
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-4761-3
  • Online ISBN 978-1-4419-9023-5
  • Buy this book on publisher's site
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