© 2011


Pathophysiology, Diagnosis, and Treatment

  • Christian R. Baumann
  • Claudio L. Bassetti
  • Thomas E. Scammell

Table of contents

  1. Front Matter
    Pages i-xv
  2. Etiology of Narcolepsy

    1. Front Matter
      Pages 1-1
    2. Emmanuel Mignot
      Pages 3-17
    3. Adriano Fontana, Heidemarie Gast, Thomas Birchler
      Pages 19-26
    4. Christelle Peyron
      Pages 27-33
  3. Neurochemistry of Narcolepsy

    1. Front Matter
      Pages 35-35
    2. Chloé Alexandre, Thomas E. Scammell
      Pages 73-84
    3. Yoshihiro Urade, Osamu Hayaishi
      Pages 93-104
  4. The Role of the Hypocretins in Sleep–Wake Regulation

    1. Front Matter
      Pages 105-105
    2. Pierre-Hervé Luppi, Patrice Fort
      Pages 107-119
    3. Matthew E. Carter, Antoine Adamantidis, Luis de Lecea
      Pages 121-128
    4. Antoine Adamantidis, Luis de Lecea
      Pages 129-137
    5. Christopher S. Leonard, Mike Kalogiannis, Kristi A. Kohlmeier
      Pages 139-151
    6. Thomas S. Kilduff, Junko Hara, Takeshi Sakurai, Xinmin Xie
      Pages 153-162
    7. Thomas E. Scammell, Chloé Alexandre
      Pages 163-174
    8. Cecilia Diniz Behn
      Pages 175-187

About this book


The field of narcolepsy has developed enormously within the last 10 years. Indeed the understanding of the basics of sleep-wake regulation and the discovery of new neurotransmitter systems (the hypocretins) has boosted research and key findings in the field, providing important insights into how sleep is regulated. Consequently narcolepsy now receives a great deal of attention from both clinicians and scientists throughout the world. Narcolepsy: Pathophysiology, Diagnosis, and Treatment not only offers an engaging and comprehensive treatment of a fascinating disorder but also includes a DVD that offers a unique and large collection of movies displaying the symptoms of narcolepsy in people and animals. Written by some of the best experts in the field, the book focuses on the pathophysiology of the problem and also provides critical, up-to-date insights on the key clinical issues: how to diagnose the disorder, how to treat it, and how to best manage psychosocial problems. The first and only guide to span the latest advances in narcolepsy, this reference provides sections in etiology, neurochemistry, the role of the hypocretins in sleep-wake regulation, animal models in narcolepsy, the key role of the hypothalamus, REM-sleep dysregulation, diagnosis and classification, and treatment. Compiled by an international group of more than 30 authors, Narcolepsy: Pathophysiology, Diagnosis, and Treatment is an indispensable resource for all clinicians and scientists with an interest in narcolepsy.


Addiction Appetite Autonomic Dopamine Hypersomnia Hypocretins Hypothalamus Metabolic regulation Narcolepsy Neurochemistry Obesity REM Reward Sleep-wake regulation

Editors and affiliations

  • Christian R. Baumann
    • 1
  • Claudio L. Bassetti
    • 2
  • Thomas E. Scammell
    • 3
  1. 1., Department of NeurologyUniversity Hospital of ZurichZurichSwitzerland
  2. 2.Neurocenter EOC of Southern Switzerland, Department of NeurologyUniversity Hospital ZurichLuganoSwitzerland
  3. 3.and Harvard Medical School, Department of NeurologyBeth Israel Deaconess Medical CenterBostonUSA

About the editors

Christian R. Baumann, MD
University Hospital of Zurich, Switzerland

Claudio L. Bassetti, MD
University Hospital of Zurich, Switzerland

Thomas E. Scammell, MD
Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA

Bibliographic information

  • Book Title Narcolepsy
  • Book Subtitle Pathophysiology, Diagnosis, and Treatment
  • Editors Christian R. Baumann
    Claudio L. Bassetti
    Thomas E. Scammell
  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2011
  • Publisher Name Springer, New York, NY
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-1-4419-8389-3
  • Softcover ISBN 978-1-4614-3180-0
  • eBook ISBN 978-1-4419-8390-9
  • Edition Number 1
  • Number of Pages XVI, 428
  • Number of Illustrations 69 b/w illustrations, 12 illustrations in colour
  • Topics Neurology
    Psychology, general
    Internal Medicine
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Consumer Packaged Goods


From the reviews:

“This comprehensive review of narcolepsy, written by scientific experts in the field of sleep disorders research and medicine, serves as guide to understanding its etiology, pathophysiology, and clinic treatment. … It is targeted primarily for sleep researchers and clinicians, as well as those who have a specific interest in narcolepsy. … With its in-depth analysis of the important areas of the etiology, diagnosis, prognosis, treatment, and management of narcolepsy, this is a useful compendium for both scientists and clinicians.” (Maureen A. Smith, Doody’s Review Service, January, 2012)