Histamine in Inflammation

  • Robin L. Thurmond

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 709)

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Katherine Figueroa, Nigel Shankley
    Pages 1-9
  3. Gerold Bongers, Iwan de Esch, Rob Leurs
    Pages 11-19
  4. Thomas Taylor-Clark
    Pages 33-41
  5. Masaharu Ohbayashi, Bita Manzouri, Kei Morohoshi, Ken Fukuda, Santa J. Ono
    Pages 43-52
  6. Paul J. Dunford, Stephen T. Holgate
    Pages 53-66
  7. Torsten Zuberbier, Marcus Maurer
    Pages 67-72
  8. Jörg Buddenkotte, Marcus Maurer, Martin Steinhoff
    Pages 73-80
  9. Elke Schneider, Maria Leite-de-Moraes, Michel Dy
    Pages 81-94
  10. Saara Nuutinen, Pertti Panula
    Pages 95-107
  11. Andras Falus, Zoltán Pós, Zsuzsanna Darvas
    Pages 109-123
  12. Fuqu Yu, Pascal Bonaventure, Robin L. Thurmond
    Pages 125-140
  13. Back Matter
    Pages 141-143

About this book


The year 2010 marks the centennial for the identification of histamine and the first glimpse of its many physiological functions. From these initial findings a rich tapestry of research has uncovered roles for histamine in almost every physiological process with new findings emerging every year. These diverse roles of histamine have made for fertile ground for the discovery of novel therapeutics, and these drugs have been so successful that the term “antihistamine” has entered the common lexicon. This volume is an attempt to give a snapshot in time as to the current understanding of the role of histamine in just one important therapeutic area—inflammation. The first three chapters provide some background context for the rest of the book starting out with a historical perspective by Figueroa and Shankley. Bongers et al provide an overview of the pharmacology of the four histamine receptors and the chapter by Hiroshi Ohtsu describes how histamine is synthesized as well as the insights derived from mice where this synthesis is disrupted. The next several chapters discuss disease areas where histamine is known to be involved. Chapter 4 by Thomas Taylor-Clark outlines the role of histamine in allergic rhinitis, an area were antihistamines are commonly used. This is also true for ocular allergy as discussed by Ohbayashi et al. Both of these chapters highlight aspects of these conditions that are still not well-controlled and suggest the utility of new antihistamines targeting other histamine receptors.


Histamine Thurmond immunity inflammation pharmacology tissue

Editors and affiliations

  • Robin L. Thurmond
    • 1
  1. 1.Johnson & Johnson Pharmaceutical Research & Development, LLCSan DiegoUSA

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