© 2011

Folding for the Synapse

  • Andreas Wyttenbach
  • Vincent O'Connor


  • Introduces important concepts of folding machineries.

  • Gives examples of the biological relevance of further chaperone functions.

  • Addresses the current view on how protein folding and misfolding contribute to synapse function and dysfunction.


Table of contents

  1. Front Matter
    Pages i-viii
  2. The Regulation of Protein (mis)folding, Aggregation and Degradation of Proteins by Molecular Chaperones

    1. Front Matter
      Pages 7-7
    2. Andreas Wyttenbach, Vincent O’Connor
      Pages 1-6
  3. The regulation of protein (mis)folding, aggregation and degradation of proteins by molecular chaperones

    1. Front Matter
      Pages 7-7
    2. Jörg Höhfeld, Nikolaus Dick, Verena Arndt
      Pages 35-48
    3. C. d’Ydewalle, J. Krishnan, V. Timmerman, L. Van Den Bosch
      Pages 49-77
  4. The Making of the Synapse: Transport of Proteins, Vesicles and Organelles

    1. Front Matter
      Pages 79-79
    2. F. Anne Stephenson, Kieran Brickley
      Pages 105-119
  5. Chaperone modalities and homeostatic mechanisms in the synaptic compartment

    1. Front Matter
      Pages 121-121
    2. Andreas Wyttenbach, Shmma Quraishe, Joanne Bailey, Vincent O’Connor
      Pages 123-144
    3. Konrad E. Zinsmaier, Mays Imad
      Pages 145-176
    4. Kevin A. Wilkinson, Jeremy M. Henley
      Pages 177-199
    5. Suzanne Tydlacka, Shi-Hua Li, Xiao-Jiang Li
      Pages 201-212
  6. Chronic neurodegeneration associated with protein misfolding and synaptic dysfunction

    1. Front Matter
      Pages 213-213
    2. P. Skehel
      Pages 215-231
    3. Dervila Glynn, A. Jennifer Morton
      Pages 233-255
    4. Nathan C. Denham, James A. R. Nicoll, Delphine Boche
      Pages 269-287

About this book


Folding for the Synapse addresses the current view on how protein folding/misfolding and its regulation by molecular chaperones contribute to synapse function and dysfunction. Molecular chaperones control de novo protein folding. However, there is increasing awareness that chaperones physiologically function to regulate protein-protein interaction cascades. This book will introduce the concept of folding machineries and also give examples of the biological relevance of further chaperone modality. Chaperones prevent misfolded proteins from accumulating into toxic intra-or extracellular aggregates in Alzheimer’s, Parkinson’s, Huntington’s, prion, and motor neuron diseases (proteinopathies). The various disease-defining protein aggregates in these proteinopathies are indicative of overstretched chaperone-and altered protein degradation systems. The consequence of this for neuronal function is discussed in several contributing chapters. Synapses regulate cell-to-cell communication in the nervous system as relatively discrete compartments that are dysfunctional during proteinopathies. Due to their partial autarky, synapses have evolved intrinsic protein folding and homeostatic capabilities that are discussed in the book.

The book servesced undergraduates, graduate students and (clinical) neuroscientists who want to develop an understanding of protein folding in health and disease.

About the Editors:
Dr. Andreas Wyttenbach holds a lectureship in Neuroscience at the University of Southampton (UK). After graduating in Biology at the University of Basel (Switzerland) he completed a PhD in Genetics and Evolution (University of Lausanne, Switzerland). During his postdoctoral research in the Departments of Medical Genetics and Biochemistry at the University of Cambridge (UK), he became inspired by the question of how protein misfolding in the CNS causes neuronal death, associated with neurological diseases. His current research concentrates on understanding how protein aggregation damages cells, with the motivation to provide a basis for therapeutic approaches that could prevent neurodegeneration.

Dr. Vincent O’Connor holds a readership at the University of Southampton. After his undergraduate studies in Physiology and Biochemistry at Reading University (UK), he trained at University College London (UK), graduating with a PhD in Neurochemistry. His postdoctoral time was spent at the Max Planck Institute for Brain Research (Frankfurt, Germany) and the National Institute for Medical Research (London, UK) investigating mechanisms of neurotransmitter release and synaptic plasticity. His current efforts focus on translating the knowledge of basic synaptic mechanisms into understanding CNS disease processes and the concept of “synaptopathies”

Editors and affiliations

  • Andreas Wyttenbach
    • 1
  • Vincent O'Connor
    • 2
  1. 1.School of Biological SciencesUniversity of SouthamptonSouthamptonUnited Kingdom
  2. 2.School of Biological SciencesUniversity of SouthamptonSouthamptonUnited Kingdom

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