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© 2010

Conjugation and Deconjugation of Ubiquitin Family Modifiers

Subcellular Biochemistry

  • Marcus Groettrup

Benefits

  • Focussed on the modifiers ubiquitin, SUMO1/2/3, NED 8, ISG15 and FAT10

  • Discusses how conjugation enzymes determine specific linkages and how they are interpreted by ubiquitin binding domains

  • Cross-talk between the ubiquitin family modification systems

Book

Part of the Subcellular Biochemistry book series (SCBI, volume 54)

Table of contents

  1. Front Matter
    Pages i-xx
  2. Frederick C. Streich Jr., Arthur L. Haas
    Pages 1-16
  3. Daniela Hoeller, Ivan Dikic
    Pages 31-40
  4. Raymond J. Deshaies, Ethan D. Emberley, Anjanabha Saha
    Pages 41-56
  5. Tilo Schmaler, Wolfgang Dubiel
    Pages 57-68
  6. Michael Düwel, Kamyar Hadian, Daniel Krappmann
    Pages 88-99
  7. Dimitris P. Xirodimas, Martin Scheffner
    Pages 116-135
  8. Frederik Eisele, Antje Schäfer, Dieter H. Wolf
    Pages 136-148
  9. Kristin E. Burns, K. Heran Darwin
    Pages 149-157
  10. Katharina Maderböck, Andrea Pichler
    Pages 158-169
  11. Tasneem Bawa-Khalfe, Edward T. H. Yeh
    Pages 170-183
  12. Stefan Jentsch, Stefan Müller
    Pages 184-194
  13. Maria Miteva, Kirstin Keusekotten, Kay Hofmann, Gerrit J. K. Praefcke, R. Jürgen Dohmen
    Pages 195-214
  14. Klaus-Peter Knobeloch
    Pages 215-227
  15. Larissa A. Durfee, Jon M. Huibregtse
    Pages 228-237
  16. Christiane Pelzer, Marcus Groettrup
    Pages 238-246

About this book

Introduction

† 1 a a 4 † 17 10 15 ubiquitin; and of 16 VCP 17 18 20 33 34 34 36 p domain. 41 42 42 43 P U 42 47 binding. C. elegans 16 In 21 22 50 51 52 53 13 and UFD 4 10 of Cdc48. 18 30 of Ufd2. COFACTORS 47 23 13 47 47 47 72 15 15 and of Spt23 p90. Ufd2 and Cdc48. In C. elegans 74 16 75 75 76 76 Ufd2 25 54 54 7 56 p47 7 7 80 30 30 81 82 82 but and CD3 26 DUB COFACTORS 30 UFD3 OTU1 4 Cdc48 30 4 OLE1. 15 27 87 REFERENCES 30 REGULATION OF UBIQUITIN MONOUBIQUITINATION UBIQUITINATION 1 32 7 S) d 33 12 13 14 15 18 19 15 20 21 35 15 15 27 15 31 32 31 33 36 monoubiquitination of pol pol 34 37 34 monoubiquitination. 20 35 trans 3 15 REFERENCES by monoubiquitination. Mol Cell; 2009. UBIQUITIN LIGASE ACTIVITY BY Nedd 1 2 of 41 5 6 8 fold. 9 13 14 edd 43 18 18 K M and k 18 22 23 K M 24 25 K M 26 edd 45 18 27 K M K D 18 25 . 8 10 M 21 28 MECHANISM AND REGULATION OF CRLs 34 41 34 edd 47 48 S. pombe 49 51 p27 and I by SCF and SCF 57 58 59 60 CTD CTD CTD CTD in Cul5 CTD CTD CTD 60 18

Keywords

Conjugation Deconjugation Groettrup Modifiers Ubiquitin enzymes regulation

Editors and affiliations

  • Marcus Groettrup
    • 1
  1. 1.Department of Biology, Division of ImmunologyUniversity of KonstanzKonstanzGermany

About the editors

MARCUS GROETTRUP is a Professor for Immunology in the Department of Biology of Konstanz University in Germany. His main interests are in the role of the immunoproteasome in antigen fragmentation and autoimmunity. Moreover, he has studied the function and conjugation of the ubiquitin‑like protein FAT10. He studied biochemistry in Tübingen and ET H Zürich and did his diploma thesis in the laboratory of H. Hengartner and R. Zinkernagel. During his PhD at the Basel Institute for Immunology with H. von Boehmer he discovered the pre T cell receptor. After habilitation at Humboldt University Berlin in the group of P‑M. Kloetzel on the topic of antigen processing he founded his own group at the Cantonal Hospital St. Gallen, Switzerland. Since 2002 he holds the Chair of Immunology at the University of Konstanz, Germany. Several prizes were awarded to Dr. Groettrup like the Award of the Sandoz Foundation for Therapeutic Research, the Karl Lohmann Prize of the German Society for Biological Chemistry, the Langener Science Prize of the Paul Ehrlich Institute, and the Research Award by the CaP CURE foundation.

Bibliographic information

  • Book Title Conjugation and Deconjugation of Ubiquitin Family Modifiers
  • Book Subtitle Subcellular Biochemistry
  • Editors Marcus Groettrup
  • Series Title Subcellular Biochemistry
  • DOI https://doi.org/10.1007/978-1-4419-6676-6
  • Copyright Information Landes Bioscience and Springer Science+Business Media, LLC 2010
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-1-4419-6675-9
  • Softcover ISBN 978-1-4939-4110-0
  • eBook ISBN 978-1-4419-6676-6
  • Series ISSN 0306-0225
  • Edition Number 1
  • Number of Pages XX, 252
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Protein Science
    Human Physiology
    Molecular Medicine
  • Buy this book on publisher's site
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