Post-Translational Modifications in Health and Disease

  • Cecilio J. Vidal

Part of the Protein Reviews book series (PRON, volume 13)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Uyen T. T. Nguyen, Andrew Goodall, Kirill Alexandrov, Daniel Abankwa
    Pages 1-37
  3. David R. Taylor, Nigel M. Hooper
    Pages 39-55
  4. C. Quiney, S. Finnegan, G. Groeger, T. G. Cotter
    Pages 57-78
  5. Yihang Li, Kenny K. K. Chung
    Pages 79-95
  6. Eva Morava, Dirk J. Lefeber, Ron A. Wevers
    Pages 97-117
  7. Federica Montanaro, Paul T. Martin
    Pages 119-143
  8. Maria Nesterova, Constantine A. Stratakis
    Pages 145-169
  9. Dirk Breitkreutz, Liora Braiman-Wiksman, Nicole Daum, Tamar Tennenbaum
    Pages 171-198
  10. Ry Y. Tweedie-Cullen, C. Sehwan Park, Isabelle M. Mansuy
    Pages 233-257
  11. Nicholas R. Bertos, Veena Sangwan, Xiang-Jiao Yang, Morag Park
    Pages 259-279
  12. Martijn van Hagen, Alfred C. O. Vertegaal
    Pages 317-340
  13. Kajan Ratnakumar, Avnish Kapoor, Emily Bernstein
    Pages 365-385
  14. Anastas Gospodinov, Zdenko Herceg
    Pages 387-409
  15. Nobuhiko Katunuma, Masae Takahashi, Tadashi Tezuka
    Pages 425-456
  16. Anthony J. Turner, Natalia N. Nalivaeva
    Pages 457-482
  17. Back Matter
    Pages 483-486

About this book


Post-translational modifications serve many different purposes in a wide variety of cellular processes,such as protein synthesis, folding, stability, the housing of prosthetic groups, vesicular trafficking,protein targeting to particular cell stores, exocytosis and endocytosis, the biogenesis of cell organelles and basal lamina. Signal transduction, with functional effects for enzyme regulation and metabolic control on the one hand, and gene expression, cell division, differentiation and apoptosis on the other, is also prominent. Post-translational Modifications in Health and Disease provides the reader with nineteen reviews that stimulate further investigations in the proteomic field - focusing on functional and pathological aspects of protein prenylation, the incorporation of glycosylphosphatidylinositol (GPI) moieties, oxidation, nitrosylation, glycosylation, and phosphorylation and dephosphorylation - with emphasis on their outcome for protein-protein interaction phenomena and down-stream effects. Additional chapters are devoted to protein ubiquitination, sumoylation and endoplasmic reticulum-associated degradation (ERAD), the influence of histone modification on gene expression and DNA repair, and proteolytic processing of intracellular and basal lamina proteins. This book will be of particular significance to researchers, clinicians, and students of biology, pharmacy and medicine.

Editors and affiliations

  • Cecilio J. Vidal
    • 1
  1. 1.Depto. Quimica InorganicaUniversidad MurciaMurciaSpain

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