© 2010

Muscle Biophysics

From Molecules to Cells

  • Dilson E. Rassier


  • Chapters contributed by world leaders in their field

  • Material covers an updated, comprehensive inclusion of techniques in both cell and molecular biophysiology

  • Represents an excellent source of information for readers intending to understand the mechanics of muscle contraction


Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 682)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Dilson E. Rassier
    Pages 1-6
  3. K. A. P. Edman
    Pages 7-40
  4. Coen A. C. Ottenheijm, Henk Granzier
    Pages 105-122
  5. W. Herzog, V. Joumaa, T. R. Leonard
    Pages 141-161
  6. Beatrice Scellini, Nicoletta Piroddi, Corrado Poggesi, Chiara Tesi
    Pages 163-174
  7. Barbara Colombini, Marta Nocella, Giulia Benelli, Giovanni Cecchi, M. Angela Bagni
    Pages 191-205
  8. K. W. Ranatunga, H. Roots, G. J. Pinniger, G. W. Offer
    Pages 207-221
  9. Håkan Westerblad, Nicolas Place, Takashi Yamada
    Pages 279-296
  10. David G. Allen, Bao-ting Zhang, Nicholas P. Whitehead
    Pages 297-313
  11. Back Matter
    Pages 343-353

About this book


Muscle contraction has been the focus of scientific investigation for more than two centuries, and major discoveries have changed the field over the years. This book centers mostly on mechanical studies, dealing with force production and regulation; it gathers studies performed by scientists who have used diverse muscle techniques, and who have shaped the field of muscle contraction throughout the past years. Starting with theoretical approaches to understand myosin molecule function and energetics, this book covers experimental work performed with single molecules, and discusses results from studies investigating basic mechanisms of contraction, using (mostly in order of appearance) isolated sarcomeres, myofibrils, and fibers are presented. The last chapters summarize studies investigating the effects of acute and chronic adaptations, including weakness and muscle disease. Muscle Biophysics represents an excellent source of information for readers intending to understand the mechanics of muscle contraction, and is a fascinating collection of chapters that will hopefully stimulate young investigators to pursue research in this exciting field of research.


ATP Herz biophysics cells mechanics physiology skeletal muscle temperature

Editors and affiliations

  • Dilson E. Rassier
    • 1
  1. 1.McGill UniversityMontrealCanada

Bibliographic information

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From the reviews:

“This text is ideally suited for muscle neurophysiologists interested in doing lab research aimed to study the strength of contraction of the actinmyosin units of skeletal and cardiac myofilaments. … This text is ideal for neurophysiologists and mycologists who have any interest in recordings. I also recommend it for those who work with muscle spindles … .” (Joseph J. Grenier,, December, 2013)