Polyploidization and Cancer

  • Randy Y. C. Poon

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 676)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Lauren M.F. Merlo, Li-san Wang, John W. Pepper, Peter S. Rabinovitch, Carlo C. Maley
    Pages 1-13
  3. Guillaume Normand, Randall W. King
    Pages 27-55
  4. Jeremy P.H. Chow, Randy Y.C. Poon
    Pages 57-71
  5. Anette Duensing, Stefan Duensing
    Pages 93-103
  6. Séverine Celton-Morizur, Chantal Desdouets
    Pages 123-135
  7. Zbigniew Darzynkiewicz, H. Dorota Halicka, Hong Zhao
    Pages 137-147
  8. Back Matter
    Pages 149-151

About this book


Limiting genome replication to once per cell cycle is vital for maintaining genome stability. Although polyploidization is of physiologically importance for several specialized cell types, inappropriate polyploidization is believed to promote aneuploidy and transformation. A growing body of evidence indicates that the surveillance mechanisms that prevent polyploidization are frequently perturbed in cancers. Progress in the past several years has unraveled some of the underlying principles that maintain genome stability. This book brings together leaders of the field to overview subjects relating to polyploidization and cancer.


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Editors and affiliations

  • Randy Y. C. Poon
    • 1
  1. 1.Department of BiochemistryHong Kong University of Science and Technology Clear Water BayHong KongChina

Bibliographic information

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