Integrins and Ion Channels

Molecular Complexes and Signaling

  • Andrea Becchetti
  • Annarosa Arcangeli

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 674)

Table of contents

  1. Front Matter
    Pages i-xix
  2. Annarosa Arcangeli, Andrea Becchetti
    Pages 1-7
  3. Chiara Di Resta, Andrea Becchetti
    Pages 9-21
  4. Alessio Masi, Riccardo Cicchi, Adolfo Carloni, Francesco Saverio Pavone, Annarosa Arcangeli
    Pages 33-42
  5. Sara Cabodi, Paola Di Stefano, Maria del Pilar Camacho Leal, Agata Tinnirello, Brigitte Bisaro, Virginia Morello et al.
    Pages 43-54
  6. Peichun Gui, Jun-Tzu Chao, Xin Wu, Yan Yang, George E. Davis, Michael J. Davis
    Pages 69-79
  7. Margaret Colden-Stanfield
    Pages 81-94
  8. Raffaella Morini, Andrea Becchetti
    Pages 95-105
  9. Back Matter
    Pages 125-127

About this book


Interdisciplinarity is more often invoked than practised. This is hardly surprising, considering the daunting vastness of modern biology. To reach a satisfactory understanding of a complex biological system, a wide spectrum of conceptual and experimental tools must be applied at different levels, from the molecular to the cellular, tissue and organismic. We believe the multifaceted regulatory interplay between integrin receptors and ion channels offers a rich and challenging field for researchers seeking broad biological perspectives. By mediating cell adhesion to the extracellular matrix, integrins regulate many developmental processes in the widest sense (from cell choice between differentiation and proliferation, to tissue remodeling and organogenesis). Rapidly growing evidence shows that frequent communication takes place between cell adhesion receptors and channel proteins. This may occur through formation of multiprotein membrane complexes that regulate ion fluxes as well as a variety of intracellular signaling pathways. In other cases, cross talk is more indirect and mediated by cellular messengers such as G proteins. These interactions are reciprocal, in that ion channel stimulation often controls integrin activation or expression. From a functional standpoint, studying the interplay between integrin receptors and ion channels clarifies how the extracellular matrix regulates processes as disparate as muscle excitability, synaptic plasticity and lymphocyte activation, just to mention a few. The derangement of these processes has many implications for pathogenesis processes, in particular for tumor invasiveness and some cardiovascular and neurologic diseases. This book provides a general introduction to the problems and methods of this blossoming field.


activation antibody biology cancer cell development ion channels membrane migration proliferation protein proteins regulation signal transduction tissue

Editors and affiliations

  • Andrea Becchetti
    • 1
  • Annarosa Arcangeli
    • 2
  1. 1.Department of Biotechnology and BiosciencesUniversity of Milano-BicoccaMilanItaly
  2. 2.Department of Experimental Pathology and OncologyUniversity of FlorenceFlorenceItlay

Bibliographic information

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