© 2012


From Pathogenesis to Comprehensive Management

  • John Varga
  • Christopher P. Denton
  • Fredrick M. Wigley

Table of contents

  1. Front Matter
    Pages i-xx
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. Christopher P. Denton, Dame Carol M. Black
      Pages 3-6
  3. Epidemiology, Genetics and Classification

    1. Front Matter
      Pages 13-13
    2. Christopher P. Denton
      Pages 15-15
    3. Jammie K. Barnes, Maureen D. Mayes
      Pages 17-28
    4. Yannick Allanore, Filemon K. Tan
      Pages 29-44
    5. Robyn T. Domsic, Thomas A. Medsger Jr.
      Pages 45-52
    6. Lorinda Chung, Jaap Fransen, Frank H. J. Van den Hoogen
      Pages 53-69
    7. Michael L. Whitfield, Robert Lafyatis
      Pages 71-81
  4. Scleroderma in Children

    1. Front Matter
      Pages 83-83
    2. Francesco Zulian
      Pages 85-92
    3. Ivan Foeldvari
      Pages 93-100
  5. Other Fibrosing Skin Conditions

    1. Front Matter
      Pages 101-101
    2. Laura K. Hummers
      Pages 103-111
    3. Amy E. Gilliam, Anita C. Gilliam
      Pages 113-135
    4. Peter J. Wermuth, Sergio A. Jimenez
      Pages 137-159
  6. Pathogenetic Basis

    1. Front Matter
      Pages 161-161
    2. John Varga
      Pages 163-164

About this book


This essential resource presents the most up-to-date information on scleroderma. A clear and concise synthesis of current concepts in pathogenesis and modern approaches to management, this book is comprised of the authoritative work of international experts. With an integrated multidisciplinary approach to comprehensive care, this book is easily accessible for health care professionals in many fields. It is a valuable resource for rheumatologists, pulmonologists, cardiologists, gastroenterologists, nephrologists and all those involved in the care of scleroderma patients.


Autoimmune Fibrosis Pulmonary Hypertension Sclerodoma Systemic sclerosis

Editors and affiliations

  • John Varga
    • 1
  • Christopher P. Denton
    • 2
  • Fredrick M. Wigley
    • 3
  1. 1.Feinberg School of MedicineNorthwestern UniversityChicagoUSA
  2. 2.Royal Free and University College, Medical SchoolUniversity College LondonLondonUnited Kingdom
  3. 3.School of Medicine, Div. RheumatologyJohns Hopkins UniversityBaltimoreUSA

Bibliographic information

  • Book Title Scleroderma
  • Book Subtitle From Pathogenesis to Comprehensive Management
  • Editors John Varga
    Christopher P. Denton
    Fredrick M. Wigley
  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2012
  • Publisher Name Springer, Boston, MA
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-1-4419-5773-3
  • Softcover ISBN 978-1-4614-9027-2
  • eBook ISBN 978-1-4419-5774-0
  • Edition Number 1
  • Number of Pages XX, 689
  • Number of Illustrations 32 b/w illustrations, 131 illustrations in colour
  • Topics Rheumatology
    Internal Medicine
    Pneumology/Respiratory System
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Internal Medicine & Dermatology


From the reviews:

“This is a very comprehensive summary of the various aspects of scleroderma, one of the most complex and challenging autoimmune disorders to diagnose and treat. … a valuable resource not only for practicing rheumatologists, but also for any physicians who treat scleroderma patients, including gastroenterologists, nephrologists, primary care doctors, and residents. … good number of illustrations and graphs make the subject more interesting and easier to comprehend. … The authors have done an incredible job summarizing all the recent research and advances in this area.” (Saba Beg, Doody’s Book Reviews, January, 2014)

“Scleroderma: From Pathogenesis to Comprehensive Management emphasises the multidisciplinary approach to comprehensive care of the scleroderma patient. The book serves as a valuable management guide and scientific review for both the ‘sclerodermaologist’/clinician and the budding researcher seeking in-depth and authoritative discussions on all aspects of scleroderma. The book is recommended to any clinician who participates in the care of our patients with this complex, yet fascinating syndrome.” (R. Saggar, European Respiratory Review, Vol. 21 (126), December, 2012)

“This book integrates the latest developments in scleroderma in terms of understanding its pathophysiology and management. The purpose is to provide an ultimate source that integrates historical management, current pathophysiology, and the possible future of better therapy. … The book is written for rheumatologists.” (Hyon Ju Park, Doody’s Review Service, March, 2012)