Microbial Endocrinology

Interkingdom Signaling in Infectious Disease and Health

  • Mark Lyte
  • Primrose P.E. Freestone

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Neil Shearer, Nicholas J. Walton
    Pages 69-87
  3. Primrose P. E. Freestone, Noura Al-Dayan, Mark Lyte
    Pages 151-166
  4. John C. Alverdy, Kathleen Romanowski, Olga Zaborina, Alexander Zaborin
    Pages 167-179
  5. Aruna Jahoor, Simon Williams, Kendra Rumbaugh
    Pages 243-268
  6. Karl V. Clemons, Jata Shankar, David A. Stevens
    Pages 269-290
  7. Back Matter
    Pages 309-316

About this book


About this book

Microbial endocrinology represents a newly emerging interdisciplinary field that is formed by the intersection of the fields of neurobiology and microbiology. It is the intent of this book to introduce a new perspective to the current understanding not only of the factors that mediate the ability of microbes to cause disease, but also to the mechanisms that maintain normal homeostasis. The discovery that microbes can both synthesize and directly respond to neuroendocrine hormones provides for a new framework with which to investigate how microorganisms interface not only with vertebrates, but also with invertebrates and even plants.

The reader will learn that neuroendocrine hormones, most commonly associated with mammals, are actually found throughout the plant, insect and microbial kingdoms to an extent that will undoubtedly surprise many, and most importantly, highlight how interactions between microbes and neuroendocrine hormones influence health and the pathophysiology of infectious disease. This book will lead its readers to the understanding that through eons of association with eukaryotic organisms, bacteria have evolved specific detection systems for neuroendocrine hormones, which they utilize not only to "sense" their environment, but also to co-op products of neurophysiological responses for their own survival.


About the Editors

Prof. Mark Lyte, Ph.D., M.S., MT(ASCP) is a Professor in the Department of Pharmacy Practice, and adjunct Professor in the Departments of Internal Medicine and Microbiology and Immunology, Texas Tech University Health Sciences Center. Prof. Lyte conducted experiments in 1991 that subsequently led him shortly thereafter to propose and found the field of microbial endocrinology. In addition to having served on scientific review panels for the National Institutes of Health and other worldwide agencies, Prof. Lyte has been awarded the Joseph Susman Memorial Award for Surgical Infectious Disease Research and was named a finalist for the NIH Director’s Pioneer Award.

Dr. Primrose Freestone, BSc(Hons), PhD, PGCE is a Lecturer in Clinical Microbiology, in the Department of Infection, Immunity and Inflammation, University of Leicester. Dr. Freestone was the first to identify tyrosine phosphorylation as a regulatory mechanism in bacteria, and to elucidate the mechanisms by which stress hormones induce bacterial growth. She is also an inventor in the fields of microbial diagnostics and dietary bioactives, and has been awarded Fellowships to develop entrepreneurial activities in life science biotechnology.


bacteria bacterial pathogens homeostasis hospital-acquired infection infection infections infectious infectious disease pathophysiology physiology signaling system

Editors and affiliations

  • Mark Lyte
    • 1
  • Primrose P.E. Freestone
    • 2
  1. 1.Health Sciences Center, School of PharmacyTexas Tech UniversityLubbockUSA
  2. 2.School of Medicine, Dept. Infection, Immunity & InflammationUniversity of LeicesterLeicesterUnited Kingdom

Bibliographic information

Industry Sectors
Health & Hospitals
Consumer Packaged Goods