Nitric Oxide (NO) and Cancer

Prognosis, Prevention, and Therapy

  • Benjamin Bonavida

Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

  1. Front Matter
    Pages i-xx
  2. General Overview

    1. Front Matter
      Pages 1-1
    2. Robert Cheng, Lisa A. Ridnour, Sharon A. Glynn, Christopher H. Switzer, Wilmarie Flores-Santana, Perwez Hussain et al.
      Pages 3-20
  3. Nitric Oxide and the Pathogenesis of Cancer

    1. Front Matter
      Pages 21-21
    2. David F. Kashatus, Christopher M. Counter
      Pages 23-38
    3. Shehla Pervin, Rajan Singh, Suvajit Sen, Gautam Chaudhuri
      Pages 39-57
    4. Emanuela Masini, Fabio Cianchi, Rosanna Mastroianni, Salvatore Cuzzocrea
      Pages 59-82
  4. Dual Roles of Nitric Oxide in Protecting or Inducing Cell Death

    1. Front Matter
      Pages 83-83
    2. Anand Krishnan V. Iyer, Neelam Azad, Liying Wang, Yon Rojanasakul
      Pages 85-102
    3. Gen-Ichiro Soma, Chie Kohchi, Hiroyuki Inagawa
      Pages 103-132
    4. Eun-Kyeong Jo, Hyun-Ock Pae, Yong Chul Lee, Hun-Taeg Chung
      Pages 133-145
    5. Christian Billard, Claire Quiney, Jean-Pierre Kolb
      Pages 169-185
  5. Role of Nitric Oxide in Metastasis

    1. Front Matter
      Pages 187-187
    2. Angel Ortega, Salvador Mena, José M. Estrela
      Pages 189-207
  6. Nitric Oxide as a Sensitizing Agent for Chem-Radio-Immunotherapy

    1. Front Matter
      Pages 235-235
    2. Marion Cortier, Lissbeth Leon, Néjia Sassi, Catherine Paul, Jean-François Jeannin, Ali Bettaieb
      Pages 253-263
  7. Prognostic Significance of NOS and NO

    1. Front Matter
      Pages 291-291
    2. Suhendan Ekmekcioglu, Elizabeth A. Grimm
      Pages 293-307
    3. Rosa M. Pascale, M. Frau, Francesco Feo
      Pages 309-328
    4. Manabu Matsumoto, Yuji Ohtsuki, Mutsuo Furihata
      Pages 329-340
  8. Therapeutic Applications of Nitric Oxide

    1. Front Matter
      Pages 359-359
    2. S. Anand, Gregory R. J. Thatcher
      Pages 361-385
    3. Hiroyasu Yasuda, Kazuhiro Yanagihara, Katsutoshi Nakayama, Tadashi Mio, Takahiko Sasaki, Masanori Asada et al.
      Pages 419-441
    4. Sanja Mijatovic, Danijela Maksimovic-Ivanic, Marco Donia, Stanislava Stosic-Grujicic, Gianni Garotta, Yousef Al-Abed et al.
      Pages 443-457
    5. Benjamin Bonavida, Stavroula Baritaki, Sara Huerta-Yepez, Mario I. Vega, Ali R. Jazirehi, James Berenson
      Pages 459-477
  9. Back Matter
    Pages 489-513

About this book


The Nobel Prize in Physiology and Medicine was awarded in 1998 to Doctors Furchgott, Ignarro, and Murad for their discoveries concerning "Nitric oxide (NO) as a signaling molecule in the cardiovascular system." NO-inducing cell signaling events within the cell producing it and the diffusibility to NO in other cells have led to the discovery of many other physiological functions in many different types of cells including cancer. Noteworthy, nitroglycerin that has been used for the treatment of chest pain and associated cardiovascular diseases is currently being investigated for its therapeutic effect in clinical studies in patients with cancer. Further, several NO donor compounds have shown, in preclinical studies, anti-tumoral chemopreventive and therapeutic activities.

"Nitric Oxide and Cancer: Prognosis, Prevention and Therapy", edited by Benjamin Bonavida, Ph.D., reviews several novel applications of NO in cancer, a new field that has rapidly gained credibility and understanding at the biochemical and molecular levels. The various chapters in this comprehensive volume (25 contributions), written by noted experts in the field, bring up-to-date our current understanding and prospective future clinical applications of NO.


apoptosis cancer cancer therapy cancer treatment carcinogenesis carcinoma cell immunotherapy leukemia melanoma metastasis pain pathogenesis prevention tumor

Editors and affiliations

  • Benjamin Bonavida
    • 1
  1. 1.Dept. Microbiology, Immunology &, Molecular GeneticsUniversity of California, Los AngelesLos AngelesUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2010
  • Publisher Name Springer, New York, NY
  • eBook Packages Medicine
  • Print ISBN 978-1-4419-1431-6
  • Online ISBN 978-1-4419-1432-3
  • Buy this book on publisher's site
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