© 2010

Structure and Function of the Neural Cell Adhesion Molecule NCAM

  • Vladimir Berezin


  • Introduction to current knowledge of extracellular and intracellular NCAM ligands and the structural basis of NCAM interactions with the fibroblast growth factor (FGF) receptor

  • Chapters are grouped into sections reflecting various aspects of NCAM structure and function, making for a straightforward approach to NCAM

  • Explores new therapeutic potential of NCAM mimetics


Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 663)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Structure and Ligands of NCAM

    1. Front Matter
      Pages 1-1
    2. Vladislav Soroka, Christina Kasper, Flemming M. Poulsen
      Pages 3-22
    3. Bettina Büttner, Rüdiger Horstkorte
      Pages 55-66
    4. Vladislav V. Kiselyov
      Pages 67-79
    5. Martin V. Hübschmann, Galina Skladchikova
      Pages 81-91
  3. NCAM and Polysialic Acid

    1. Front Matter
      Pages 94-94
    2. Herbert Hildebrandt, Martina Mühlenhoff, Rita Gerardy-Schahn
      Pages 95-109
    3. Eduardo Gascon, Laszlo Vutskits, Jozsef Zoltan Kiss
      Pages 127-136
    4. Abderrahman El Maarouf, Urs Rutishauser
      Pages 137-147
  4. NCAM-Mediated Signal Transduction

    1. Front Matter
      Pages 150-150
    2. Dorte Kornerup Ditlevsen, Kateryna Kolkova
      Pages 151-168
    3. Gro Klitgaard Povlsen, Dorte Kornerup Ditlevsen
      Pages 183-198
  5. NCAM Metabolism

    1. Front Matter
      Pages 212-212
    2. Kateryna Kolkova
      Pages 213-225
    3. Thomas Secher
      Pages 227-242

About this book


Adhesive interactions are important for cell trafficking, differentiation, function and tissue formation. In the nervous system, many cell adhesion molecules (CAMs) are involved in migration of neuroblasts, outgrowth and fasciculation of neuronal processes, formation of synapses and rearrangements of synaptic contacts associated with plasticity including learning and memory. More than eighty CAMs were found to be localized at synaptic sites, where they in a regulated manner bridge pre- and postsynaptic specializations thereby modulating synaptic function. Structure and Function of the Neural Cell Adhesion Molecule NCAM describes recent developments concerning structural, functional and possible therapeutic aspects of one particular CAM, the neural cell adhesion molecule (NCAM). NCAM is one of the first identified and most studied CAMs, and this book is the first attempt to collectively summarize our current knowledge of this important cell adhesion molecule.


Nervous System adhesion berezin cell molecule ncam neural regulation

Editors and affiliations

  • Vladimir Berezin
    • 1
  1. 1.Panum Institute, Dept. Regenerative MedicineUniversity of CopenhagenKoebenhavn NDenmark

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