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The Physics of Proteins

An Introduction to Biological Physics and Molecular Biophysics

  • Hans Frauenfelder
  • Shirley S. Chan
  • Winnie S. Chan

Part of the Biological and Medical Physics, Biomedical Engineering book series (BIOMEDICAL)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Biomolecules

    1. Front Matter
      Pages 1-2
    2. Hans Frauenfelder
      Pages 5-7
    3. Hans Frauenfelder
      Pages 9-11
    4. Hans Frauenfelder
      Pages 19-35
    5. Hans Frauenfelder
      Pages 37-46
    6. Hans Frauenfelder
      Pages 49-52
    7. Hans Frauenfelder
      Pages 53-58
  3. Spatial Structure of Proteins: Measurement and Consequence

    1. Front Matter
      Pages 61-62
    2. Hans Frauenfelder
      Pages 65-73
    3. Hans Frauenfelder
      Pages 75-81
    4. Hans Frauenfelder
      Pages 83-91
  4. The Energy Landscape and Dynamics of Proteins

    1. Front Matter
      Pages 93-94
    2. Hans Frauenfelder
      Pages 97-112
    3. Hans Frauenfelder
      Pages 113-124
    4. Hans Frauenfelder
      Pages 125-155
    5. Hans Frauenfelder
      Pages 157-169
  5. Function and Dynamics

    1. Front Matter
      Pages 171-172
    2. Hans Frauenfelder
      Pages 175-196
    3. Hans Frauenfelder
      Pages 199-208
    4. Hans Frauenfelder
      Pages 209-236
  6. Appendices: Tools and Concepts for the Physics of Proteins

    1. Front Matter
      Pages 237-240
    2. Hans Frauenfelder
      Pages 243-256
    3. Hans Frauenfelder
      Pages 257-261
    4. Hans Frauenfelder
      Pages 263-277
    5. Hans Frauenfelder
      Pages 279-306
    6. Hans Frauenfelder
      Pages 309-313
    7. Hans Frauenfelder
      Pages 315-320
    8. Hans Frauenfelder
      Pages 323-339
    9. Hans Frauenfelder
      Pages 341-361
    10. Hans Frauenfelder
      Pages 363-376
    11. Hans Frauenfelder
      Pages 377-391
    12. Hans Frauenfelder
      Pages 393-414
    13. Hans Frauenfelder
      Pages 437-440
  7. Back Matter
    Pages 443-448

About this book

Introduction

Physics and the life sciences have established new connections within the past few decades, resulting in biological physics as an established subfield with strong groups working in many physics departments. These interactions between physics and biology form a two-way street with physics providing new tools and concepts for understanding life, while biological systems can yield new insights into the physics of complex systems. To address the challenges of this interdisciplinary area, The Physics of Proteins: An Introduction to Biological Physics and Molecular Biophysics is divided into three interconnected sections. In Parts I and II, early chapters introduce the terminology and describe the main biological systems that physicists will encounter. Similarities between biomolecules, glasses, and solids are stressed with an emphasis on the fundamental concepts of living systems. The central section (Parts III and IV) delves into the dynamics of complex systems. A main theme is the realization that biological systems, in particular proteins, do not exist in unique conformations but can assume a very large number of slightly different structures. This complexity is captured in the concept of a free energy landscape and leads to the conclusion that fluctuations are crucial for the functioning of biological systems. The final chapter of this section challenges the reader to apply these concepts to a problem that appears in the current literature. An extensive series of appendices (Part V) provide descriptions of the key physical tools and analytical methods that have proven powerful in the study of the physics of proteins. The appendices are designed to be consulted throughout the section on protein dynamics without breaking the deductive flow of the logic in the central section of the book.

Keywords

Secondary structure Termination X-ray biophysics energy landscapes imaging living systems magnetic resonance microscopy protein physics proteins tertiary structure thermodynamics

Authors and affiliations

  • Hans Frauenfelder
    • 1
  1. 1., Theory DivisionLos Alamos National LaboratoryLos AlamosUSA

Editors and affiliations

  • Shirley S. Chan
    • 1
  • Winnie S. Chan
    • 2
  1. 1.Technology, Department of PhysicsHong Kong University of Science &KowloonHong Kong/PR China
  2. 2., Grainger Engineering Library InformationUniversity of Illinois at Urbana-ChampaiUrbanaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4419-1044-8
  • Copyright Information Springer-Verlag New York 2010
  • Publisher Name Springer, New York, NY
  • eBook Packages Physics and Astronomy
  • Print ISBN 978-1-4419-1043-1
  • Online ISBN 978-1-4419-1044-8
  • Series Print ISSN 1618-7210
  • Series Online ISSN 2197-5647
  • Buy this book on publisher's site
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