© 2010

Cancer Genome and Tumor Microenvironment

  • Andrei Thomas-Tikhonenko


  • Reviews how tumor microenvironment and progression are “hard-wired” at the genetic level


Part of the Cancer Genetics book series (CANGENETICS)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Opening Remarks

    1. Front Matter
      Pages 1-1
    2. Andrei Thomas-Tikhonenko
      Pages 3-8
  3. Breaking Away: Epithelial-Mesenchymal Transition

  4. Coming up for Air: Hypoxia and Angiogenesis

    1. Front Matter
      Pages 117-117
    2. Prema Sundaram, Chi V. Dang, Andrei Thomas-Tikhonenko
      Pages 167-187
    3. Jose G. Teodoro, Sara K. Evans, Michael R. Green
      Pages 189-216
    4. Greg H. Enders
      Pages 217-229
  5. Gaining New Ground: Metastasis and Stromal Cell Interactions

    1. Front Matter
      Pages 231-231
    2. Rajeev Kaul, Masanao Murakami, Pankaj Kumar, Erle S. Robertson
      Pages 233-271
    3. Mandira Ray, J G Garcia, Ravi Salgia
      Pages 273-292
    4. Antoni Xavier Torres-Collado, M. Luisa Iruela-Arispe
      Pages 293-314
    5. Michele Jacob, Ellen Puré
      Pages 315-333
    6. Qinghua Zeng, Boris Pasche
      Pages 335-348

About this book


Oncogenes and tumor suppressor genes had been traditionally studied in the context of cell proliferation, differentiation, senescence, and survival, four relatively cell-autonomous processes. Consequently, in the late ‘80s-mid ‘90s, neoplastic growth was described largely as a net imbalance between cell accumulation and loss, brought about through mutations in cancer genes. In the last ten years, a more holistic understanding of cancer slowly emerged, stressing the importance of interactions between neoplastic and various stromal components: extracellular matrix, basement membranes, fibroblasts, endothelial cells of blood and lymphatic vessels, tumor-infiltrating lymphocytes, etc . Nevertheless, the commonly held view is that changes in tumor microenvironment are "soft-wired", i.e. epigenetic in nature and often reversible. Yet, there exists a large body of evidence suggesting that well-known mutations in cancer genes profoundly affect tumor milieu. In fact, these cell-extrinsic changes might be one of the primary reasons such mutations are preserved in late-stage tumors. Cancer Genome and Tumor Microenvironment reviews how tumor microenvironment and progression can be "hard-wired", i.e. genetically controlled.


Chromosom angiogenesis cell genes lymphocytes lymphoma melanoma metastasis senescence tumor tumor progression

Editors and affiliations

  • Andrei Thomas-Tikhonenko
    • 1
  1. 1.Children's Hospital of PhiladelphiaPhiladelphiaU.S.A.

Bibliographic information

  • Book Title Cancer Genome and Tumor Microenvironment
  • Editors Andrei Thomas-Tikhonenko
  • Series Title Cancer Genetics
  • Series Abbreviated Title Cancer Genetics
  • DOI
  • Copyright Information Springer-Verlag New York 2010
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-1-4419-0710-3
  • Softcover ISBN 978-1-4614-2524-3
  • eBook ISBN 978-1-4419-0711-0
  • Edition Number 1
  • Number of Pages IX, 480
  • Number of Illustrations 29 b/w illustrations, 16 illustrations in colour
  • Topics Cancer Research
  • Buy this book on publisher's site
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From the reviews:

“This book compiles recent works on genetic alterations that have been associated with carcinogenesis and attempts to present these in the context of the interaction of tumor cells with their microenvironment. The book provides a great deal of information on specific subjects of research, and is very useful as a reference. … The audience includes scientists and physicians involved in basic and translational research.” (Khashayarsha Khazaie, Doody’s Review Service, July, 2010)

“This book amends a space of nowaday cancer bibliography in the area of tumor microenvironment as it provides detailed overview of crucial steps of tumorigenesis. Book consists of 20 chapters that are divided into 4 main parts in addition to introductory editor’s part providing short characteristics of particular chapters and closing one. … The book is very useful for PhD students and for all researchers who intend to be more oriented in advances of molecular oncology. Therefore the book is highly recommended.” (J. Sedlák, Neoplasma, February, 2011)