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© 2009

Development and Engineering of Dopamine Neurons

  • R. Jeroen Pasterkamp
  • Marten P. Smidt
  • J. Peter H. Burbach
Book

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 651)

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Jörn Schweitzer, Wolfgang Driever
    Pages 1-14
  3. John W. Cave, Harriet Baker
    Pages 15-35
  4. Antonio Simeone, Eduardo Puelles, Dario Acampora, Daniela Omodei, Pietro Mancuso, Luca Giovanni Di Giovannantonio
    Pages 36-46
  5. Marten P. Smidt, J. Peter, H. Burbach
    Pages 47-57
  6. Horst H. Simon, Kambiz N. Alavian
    Pages 66-72
  7. Oliver von Bohlen, Klaus Unsicker
    Pages 73-80
  8. Eleni Roussa, Oliver von Bohlen und Halback, Kerstin Krieglstein
    Pages 81-90
  9. Asheeta A. Prasad, R. Jeroen Pasterkamp
    Pages 91-100
  10. Sonja Kriks, Lorenz Studer
    Pages 101-111
  11. Back Matter
    Pages 125-127

About this book

Introduction

Theneurotransmitter dopamine has just celebrated its 50thbirthday. The discovery of dopamine as a neuronal entity in the late 1950s and the notion that it serves in neurotransmission has been a milestone in the field of neuroscience research. This milestone marked the beginning of an era that explored the brain as an integrated collection of neuronal systems that one could distinguish on basis of neurotransm- ter identities, and importantly, in which one started to be able to pinpoint the seat of brain disease. The mesodiencephalic dopaminergic (mdDA) system, previously designated as midbraindopaminergic system, has received much attention since its discovery. The initial identification of dopamine as a neurotransmitter in the central nervous system (CNS) and its relevance to psychiatric and neurological disorders have stimulated a plethora of neurochemical, pharmacological and genetic studies into the function of dopamine neurons and theirprojections. In the last decade, studies on gene expression and development have further increased the knowledge of this neuronal population and have unmasked a new level of complexity. The start of the molecular dissection of the mdDA system has been marked by the cloning and characterization ofNurrl and Pitx3. These transcription factors were shown to have a critical function during mdDA development. These initial studies have been followed by the identification of many other proteins, which have a crucial function in the creation of a dopamine neuron permissive region, induction of precursors, induction of terminaldifferent- tion and finally maintenance of the mdDA neuronal pool.

Keywords

Nervous System Parkinson forebrain neurons neuroscience

Editors and affiliations

  • R. Jeroen Pasterkamp
    • 1
  • Marten P. Smidt
    • 1
  • J. Peter H. Burbach
    • 1
  1. 1.Rudolf Magnus Institute of Neuroscience Department of Neuroscience and PharmacologyUniversity Medical Center UtrechtUtrechtThe Netherlands

About the editors

R. Jeroen Pasterkamp is an Assistant Professor at the Rudolf Magnus
Institute of Neuroscience, Department of Neuroscience and Pharmacology, University
Medical Center Utrecht, Utrecht, The Netherlands. The focus of his laboratory is
directed towards understanding the molecular and intracellular signaling events
involved in the formation of neuronal connections with a particular focus on the
developing dopamine system. His research team concentrates on the developing
mouse embryo using an integrated approach involving molecular biology, cell biology,
in vivo functional proteomics, and mouse genetics. He received his PhD from
the Netherlands Institute for Neurosciences (Amsterdam, The Netherlands) and
did his Postdoctoral at the Department of Neuroscience, Johns Hopkins University
School of Medicine, Baltimore, USA.

Marten Smidt is an Associate Professor at the Rudolf Magnus Institute
of Neuroscience, Department of Neuroscience and Pharmacology, University
Medical Center Utrecht, Utrecht, The Netherlands. The focus of his laboratory is
directed towards understanding the developmental processes that underlie neuronal
differentiation and specification. The main focus has been the development of
mesodiencephalic dopamine neurons. The work includes mouse genetics, molecular
genetics and molecular biology. Marten Smidt received his PhD from the University
of Groningen (Groningen, The Netherlands) and did his postdoctoral at Utrecht
University, Department of Medical Pharmacology, Rudolf Magnus Institute of
Neuroscience (Utrecht, The Netherlands).

J. Peter H. Burbach is professor of Molecular Neuroscience at Utrecht
University and head of the Department of Neuroscience and Pharmacology, Rudolf
Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The
Netherlands. His research interests concern the role of transcription factors in development and regulation of peptidergic and dopaminergic neurons, and the molecular
mechanisms of human neurodevelopmental disorders. He received his PhD from
Utrecht University and did postdoctoral work at the Clinical Research Institute of
Montreal, Canada. He obtained professorships in Molecular Biology and Molecular
Neuroendocrinology. Since 2001 he is a Summer scientist at the Marine Biological
Laboratory, Woods Hole, MA, USA.

Bibliographic information

  • Book Title Development and Engineering of Dopamine Neurons
  • Editors Jeroen Pasterkamp
    Marten P. Smidt
    J. Peter H. Burbach
  • Series Title Advances in Experimental Medicine and Biology
  • DOI https://doi.org/10.1007/978-1-4419-0322-8
  • Copyright Information Springer-Verlag New York 2009
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-1-4419-0321-1
  • Softcover ISBN 978-1-4899-8180-6
  • eBook ISBN 978-1-4419-0322-8
  • Series ISSN 0065-2598
  • Edition Number 1
  • Number of Pages XVIII, 127
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Biomedicine, general
  • Buy this book on publisher's site
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