Systems Biology and Biotechnology of Escherichia coli

  • Sang Yup Lee

Table of contents

  1. Front Matter
    Pages I-XXI
  2. Sung Ho Yoon, Haeyoung Jeong, Soon-Kyeong Kwon, Jihyun F. Kim
    Pages 1-17
  3. Bong Hyun Sung, Jun Hyoung Lee, Sun Chang Kim
    Pages 19-40
  4. Nobuyoshi Ishii, Masaru Tomita
    Pages 41-57
  5. Allan Matte, Irena Ekiel, Zongchao Jia, Kalle Gehring, Miroslaw Cygler
    Pages 59-86
  6. Hirotada Mori, Natsuko Yamamoto, Hitomi Dose, Kenji Nakahigashi, Kirill A. Datsenko, Barry L. Wanner
    Pages 87-97
  7. Hawoong Jeong
    Pages 113-132
  8. Michael Y. Galperin
    Pages 133-148
  9. Adam M. Feist, Ines Thiele, Bernhard Ø Palsson
    Pages 149-176
  10. Ekaterina A. Mogilevskaya, Kirill V. Peskov, Eugeniy A. Metelkin, Galina V. Lebedeva, Tatiana Y. Plyusnina, Igor I. Goryanin et al.
    Pages 177-207
  11. Timo Hardiman, Karin Lemuth, Martin Siemann-Herzberg, Matthias Reuss
    Pages 209-235
  12. M. Kenyon Applebee, Bernhard Ø Palsson
    Pages 237-256
  13. Douglas F. Browning, David C. Grainger, Stephen J. W. Busby
    Pages 257-271
  14. Dave Siak-Wei Ow, Dong-Yup Lee, Hsiu-Hui Tung, Sue Lin-Chao
    Pages 273-294
  15. Elena Garcìa-Fruitòs, Nuria Gonzàlez-Montalbàn, Mònica Martìnez-Alonso, Ursula Rinas, Antonio Villaverde
    Pages 295-326
  16. Jeffrey J. Tabor, Eli S. Groban, Christopher A. Voigt
    Pages 401-439
  17. Sang Yup Lee, Jin Hwan Park
    Pages 441-453
  18. Back Matter
    Pages 455-462

About this book


Systems biology is changing the way biological systems are studied by allowing us to examine the cell and organism as a whole. Systems biotechnology allows optimal design and development of upstream to downstream bioprocesses by taking a systems-approach. E. coli has been a model organism for almost all biological and biotechnological studies. This book brings together for the first time the state-of-the-art reviews by the world-leading experts on systems biology and biotechnological applications of E. coli. The topics covered include genomics and functional genomics, resources for systems biology, network analysis, genome-scale metabolic reconstruction, modelling and simulation, dynamic modelling and simulation, systems-level analysis of evolution, plasmids and expression systems, protein synthesis, production and export, engineering the central metabolism, synthetic biology, and systems metabolic engineering of E. coli. This book provides readers with guidance on how a complex biological system can be studied using E. coli as a model organism. It also presents how to perform synthetic biology and systems metabolic engineering studies on E. coli with successful examples, the approaches of which can be extended to other organisms. This book will be a complete resource for anyone interested in systems biology and biotechnology.


Expression Glucose Proteomics biology biotechnology design metabolism

Editors and affiliations

  • Sang Yup Lee
    • 1
  1. 1.Dept. of Chemical and Biomolecular EngineeringKorea Advanced Institute of Science and Technology (KAIST)Yuseong-guRepublic of Korea (South Korea)

Bibliographic information

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