© 2008

Lipids in Health and Disease

  • Peter J. Quinn
  • Xiaoyuan Wang
  • The lipids represent targets for cell regulation

  • Their role in signaling processes increasingly recognized

  • Their role in cell-cell recognition and social behaviour of cells is identified

  • Potential therapeutic targets for gene transfection


Part of the Subcellular Biochemistry book series (SCBI, volume 49)

Table of contents

  1. Front Matter
    Pages I-XXI
  2. Fatty Acids

    1. Front Matter
      Pages 1-1
    2. Hervé Guillou, Pascal G.P. Martin, Thierry Pineau
      Pages 3-47
    3. María Cecilia Mansilla, Claudia E. Banchio, Diego de Mendoza
      Pages 71-99
    4. Filomena Fezza, Chiara De Simone, Daniele Amadio, Mauro Maccarrone
      Pages 101-132
    5. Jing X. Kang, Karsten H. Weylandt
      Pages 133-143
    6. Sriram Krishnamoorthy, Kenneth V. Honn
      Pages 145-168
    7. Joy L. Little, Steven J. Kridel
      Pages 169-194
  3. Phospholipids

    1. Front Matter
      Pages 195-195
    2. Rao Muralikrishna Adibhatla, J. F. Hatcher
      Pages 241-268
    3. Tetsuji Mutoh, Jerold Chun
      Pages 269-297
    4. Paramjit S. Tappia, Tushi Singal
      Pages 299-324
    5. Gilbert O. Fruhwirth, Albin Hermetter
      Pages 351-367
  4. Sphingolipids

    1. Front Matter
      Pages 369-369
    2. Tilla S. Worgall
      Pages 371-385
    3. Natasha C. Lucki, Marion B. Sewer
      Pages 387-412
    4. Sahar A. Saddoughi, Pengfei Song, Besim Ogretmen
      Pages 413-440

About this book


Lipids are functionally versatile molecules. They have evolved from relatively simple hydrocarbons that serve as depot storages of metabolites and barriers to the permeation of solutes into complex compounds that perform a variety of signalling functions in higher organisms. This volume is devoted to the polar lipids and their constituents. We have omitted the neutral lipids like fats and oils because their function is generally to act as deposits of metabolizable substrates. The sterols are also outside the scope of the present volume and the reader is referred to volume 28 of this series which is the subject of cholesterol. The polar lipids are comprised of fatty acids attached to either glycerol or sphingosine. The fatty acids themselves constitute an important reservoir of substrates for conversion into families of signalling and modulating molecules including the eicosanoids amongst which are the prostaglandins, thromboxanes and leucotrienes. The way fatty acid metabolism is regulated in the liver and how fatty acids are desaturated are subjects considered in the first part of this volume. This section also deals with the modulation of protein function and inflammation by unsaturated fatty acids and their derivatives. New insights into the role of fatty acid synthesis and eicosenoid function in tumour progression and metastasis are presented.


Activation Lipid Metabolism Oxidation enzymes regulation transcription

Editors and affiliations

  • Peter J. Quinn
    • 1
  • Xiaoyuan Wang
    • 2
  1. 1.Biochemistry DepartmentKing’s College LondonUK
  2. 2.State Key Laboratory of Food Science and TechnologyJiangnan UniversityChina

Bibliographic information

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