© 2009

Aldol Reactions

  • Rainer Mahrwald
  • Fundamentals of the aldol addition are presented as well as brand new developments in the field of stereoselective aldol additions

  • The use of metal enolates, Lewis acids, Lewis bases and enzymes in current total syntheses of natural products is discussed in detail

  • The tremendous success of organocatalyzed aldol additions is highlighted under the aspects of selectivity and practicability in total syntheses


Table of contents

About this book


Aldol Reactions provides a comprehensive up-to-date overview of aldol reactions including:

  • Application of different metal enolates
  • Catalytic aldol additions catalyzed by different Lewis acids and Lewis bases
  • Enantioselective direct aldol additions
  • Antibodies and enzyme catalyzed aldol additions
  • The recent aggressive development of organocatalyzed aldol additions.

The power of each method is demonstrated by several applications in total synthesis of natural products. The pros and cons of these methodologies with regard to stereoselectivity, regioselectivity and application in total synthesis of natural products are discussed. Great importance is set to the diverse possibilities of the manual of aldol reaction to install required configurations in complicated natural product synthesis.


Aldol Additions Aldol Methodologies Base Enzymes Lewis Acids Lewis Bases Metal Enolates Organocatalysis natural product

Editors and affiliations

  • Rainer Mahrwald
    • 1
  1. 1.Institute of ChemistryHumboldt UniversityBerlinGermany

Bibliographic information

Industry Sectors
Chemical Manufacturing
Consumer Packaged Goods
Oil, Gas & Geosciences