© 2008

Immunity Against Mucosal Pathogens

  • Michael Vajdy

Table of contents

  1. Front Matter
    Pages I-XVI
  2. Structure and Cells of Mucosal Tissues

    1. Front Matter
      Pages 1-1
  3. Immunology of Mucosal Tissues

    1. Front Matter
      Pages 31-31
    2. Per Brandtzaeg, Finn-Eirik Johansen
      Pages 33-76
    3. Rajesh Singh, James W. Lillard
      Pages 77-133
    4. Dennis K. Lanning, Kari M. Severson, Katherine L. Knight
      Pages 135-150
  4. Gastrointestinal Pathogens

    1. Front Matter
      Pages 151-151
    2. Jan Holmgren, John D. Clemens
      Pages 173-194
    3. Paolo Ruggiero
      Pages 195-218
    4. Juan S. Leon, Menira Souza, Qiuhong Wang, Emily R. Smith, Linda J. Saif, Christine L. Moe
      Pages 219-262
    5. Ana María González, Marli S.P. Azevedo, Linda J. Saif
      Pages 263-297
  5. Respiratory Pathogens

    1. Front Matter
      Pages 299-299
    2. Jacinta E. Cooper, Edward N. Janoff
      Pages 301-321
    3. Barbara Baudner, Rino Rappuoli
      Pages 323-365
    4. Prosper N. Boyaka, Alexandra Duverger, Estelle Cormet-Boyaka, Jean-Nicolas Tournier
      Pages 367-381
    5. Indresh K. Srivastava, Elaine Kan, Isha N. Srivastava, Jimna Cisto, Zohar Biron
      Pages 383-414
    6. Michael Vajdy
      Pages 415-430

About this book


Surprisingly what separates us from the open environment all around us sometimes is a single layer of epithelial cells. It is at these seemingly fragile sites that most pathogens, including HIV, influenza, emerging and biodefense agents, gain access to our inside milieu. While there are major similarities between the cells and the immune responses generated at the mucosal membranes of the gastrointestinal and respiratory tracts together with the genitourinary tract, there are also important differences. Knowledge of these differences and similarities is required in order to understand the interactions between us, as the host, and the pathogens that attack through each tract, and how our immune system reacts to each of them. Whether we want to devise rational prophylactic or therapeutic vaccines or treatments to either prevent or treat mucosal infections we must acquire such knowledge. This is the rationale behind putting this book together.

This book will provide the readers in the areas of vaccinology, virology, bacteriology, epidemiology, immunology and mucosal immunology within academia (undergraduate, graduate, post doctoral fellows and professors), as well as preclinical and clinical scientists in vaccine and drug industries a thorough appreciation of the mucosal immune system and its importance in protecting humans against mucosal pathogens.


HIV Virus bacteria bacteriology infection infections vaccine

Editors and affiliations

  • Michael Vajdy
    • 1
  1. 1.Davis School of Medicine Department of Medical Microbiology and ImmunologyUniversity of CaliforniaUSA

Bibliographic information

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