© 2008

Innate and Adaptive Immunity in the Tumor Microenvironment

  • Eitan Yefenof


  • Novel topic in bio-medical research

  • Fundamental and practical issues related to cancer therapy

  • Of interest to students, researchers and physicians


Part of the The Tumor Microenvironment book series (TTME, volume 1)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Katja Engelmann, Olivera J. Finn
    Pages 91-119
  3. Silvia Selleri, Sara Deola, Cristiano Rumio, Francesco M. Marincola
    Pages 139-155
  4. Michal Lotem, Arthur Machlenkin, Shoshana Frankenburg, Tamar Peretz
    Pages 157-170
  5. Roi Gazit, Ofer Mandelboim
    Pages 171-193
  6. Back Matter
    Pages 211-212

About this book


Cancer cells are continuously interacting with the immune system of the host. These interactions can be regarded as a double edged sword. On the one hand, innate and adaptive immune responses act to protect the host by attempting rejection of the tumor. On the other hand, inflammatory cells and proteins stimulate multiplication and dissemination of cancer cells, thereby accelerating the progression of the disease. Traditionally, the interplay between cancer cells and host immunity has been studied systemically, with no particular attention to the site at which a given tumor develops. Recent studies, however, indicate that the tumor microenvironment is unique in providing both supportive and inhibitory factors that determine the fate of the tumor and its host. Accordingly, microenvironmental immunity that operates inside and around a tumor plays a crucial role in cancer development and progression. The aim of the present volume is to compile reviews on innate and adaptive immune responses at the tumor microenvironment with emphasis on positive and negative outcomes that affect the progression of the disease. These reviews have been solicited from experts in the field who published original research studies focusing on these issues.


Antigen Immune System Immunity apoptosis proteins regulation tumor growth tumor microenvironment, adaptive immunity, innate immunity

Editors and affiliations

  • Eitan Yefenof
    • 1
  1. 1.Lautenberg Center for General and Tumor ImmunologyHebrew University—Hadassah Medical SchoolJerusalemIsrael

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