The Paraoxonases: Their Role in Disease Development and Xenobiotic Metabolism

  • Bharti Mackness
  • Mike Mackness
  • Michael Aviram
  • György Paragh

Part of the Proteins And Cell Regulation book series (PROR, volume 6)

Table of contents

  1. Front Matter
    Pages I-XV
  2. The Bert La Du Memorial Lecture

    1. Front Matter
      Pages 1-1
    2. C.E. Furlong
      Pages 3-31
  3. PONs and Atherosclerosis

    1. Front Matter
      Pages 33-33
    2. B. Mackness, M.I. Mackness
      Pages 51-60
    3. Eser Yildirim Sozmen, Ferhan Girgin Sagin, Meral Kayikcioglu, Bulent Sozmen
      Pages 61-73
    4. N. Bourquard, D.M. Shih, C.J. Ng, N. Villa-Garcia, K. Nakamura, D.A. Stoltz et al.
      Pages 103-128
    5. A. Alipour, B. Coll, A.P. Rietveld, J. Marsillach, J. Camps, J. Joven et al.
      Pages 129-138
    6. M. Roest, H.A.M. Voorbij
      Pages 139-147
  4. PON1 Structure

    1. Front Matter
      Pages 149-149
    2. David T. Yeung, David E. Lenz, Douglas M. Cerasoli
      Pages 151-170
    3. D. Rochu, E. Chabriere, M. Elias, F. Renault, C. Clery-Barraud, P. Masson
      Pages 171-183
  5. PONs in Disease other than Atherosclerosis

    1. Front Matter
      Pages 185-185
    2. J. Marsillach, S. Parra, N. Ferré, B. Coll, C. Alonso-Villaverde, J. Joven et al.
      Pages 187-198
    3. I. Seres, T. Fulop, G. Paragh, A. Khalil
      Pages 199-206
  6. PON and Toxicology

    1. Front Matter
      Pages 207-207
    2. L.G. Costa, T.B. Cole, K.L. Jansen, C.E. Furlong
      Pages 209-220
    3. A.F. Hernández, O. López, G. Pena, J.L. Serrano, T. Parrón, L. Rodrigo et al.
      Pages 221-237
  7. PON-Genetics and Regulation

    1. Front Matter
      Pages 239-239
    2. S.P. Deakin, R.W. James
      Pages 241-250
    3. G. Paragh, M. Harangi, I. Seres
      Pages 251-266
    4. C.E. Furlong, R.J Richter, W.-F. Li, V.H. Brophy, C. Carlson, M. Rieder et al.
      Pages 267-281
  8. PONs Biochemistry

    1. Front Matter
      Pages 295-295
    2. D.A. Stoltz, E.A. Ozer, J. Zabner
      Pages 307-319
  9. Back Matter
    Pages 321-325

About this book


Research into the paraoxonase (PON) multigene family has really only blossomed in the last 10 years. Before this time only PON1 was known and research was restricted to toxicologists investigating the metabolism of organophosphate insecticides and nerve gases and a few “mad” scientists searching for “natural” substrates.

Since this time two new members PON2 and PON3 have been discovered, all 3 PONs have been shown to act as antioxidants and the PON family has taken centre stage as major players in the development of a wide variety of diseases such as cardiovascular disease, diabetes mellitus, rheumatism, Alzheimer and many more while remaining important in determining organophosphate toxicity.

In September 2006 the 2nd International Conference on Paraoxonases took place in Hajdúszoboszló, Hungary, bringing together the world's foremost experts in the field. The current book is a distillation of the plenary lectures which took place at the meeting, resulting in a comprehensive up to date, state of the art review of current paraoxonase research.


Diabetes Diabetes mellitus HIV biochemistry cardiovascular enzymes metabolism

Editors and affiliations

  • Bharti Mackness
    • 1
  • Mike Mackness
    • 2
  • Michael Aviram
    • 3
  • György Paragh
    • 4
  1. 1.University of ManchesterU.K
  2. 2.University of ManchesterU.K
  3. 3.Technion Faculty of MedicineHaifaIsrael
  4. 4.University of DebrecenHungary

Bibliographic information

Industry Sectors
Health & Hospitals
Internal Medicine & Dermatology