© 2008

Programmed Cell Death in Cancer Progression and Therapy


Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 615)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Zahra Zakeri, Richard A. Lockshin
    Pages 1-11
  3. Guy S. Salvesen, Stefan J. Riedl
    Pages 13-23
  4. Anas Chalah, Roya Khosravi-Far
    Pages 25-45
  5. Armelle Melet, Keli Song, Octavian Bucur, Zainab Jagani, Alexandra R. Grassian, Roya Khosravi-Far
    Pages 47-79
  6. Peter Hersey, Xu Dong Zhang, Nizar Mhaidat
    Pages 105-126
  7. Robin C. Humphreys, Wendy Halpern
    Pages 127-158
  8. Kageaki Kuribayashi, Wafik S. El-Deiry
    Pages 201-221
  9. Yongjun Fan, Jui Dutta, Nupur Gupta, Gaofeng Fan, Céline Gélinas
    Pages 223-250
  10. Dharminder Chauhan, Teru Hideshima, Kenneth C. Anderson
    Pages 251-260
  11. Derek M. Dykxhoorn, Dipanjan Chowdhury, Judy Lieberman
    Pages 299-329
  12. Zainab Jagani, Roya Khosravi-Far
    Pages 331-344
  13. Back Matter
    Pages 345-356

About this book


Programmed cell death (PCD) plays pivotal roles in tumor progression, cancer therapeutics and resistance of tumor cells to therapy. With the discovery of key mechanisms that are involved in mediating PCD and in promoting resistance to therapy, design of therapeutic approaches for promoting tumor-selective cell death has risen dramatically. With this book, we give a comprehensive overview of the mechanisms that are involved in mediating and regulating PCD in cancer. We also provide a detailed indication of the utility of PCD in cancer therapy. This book will be a valuable resource for researchers investigating the role of PCD in cancer and other diseases, researchers investigating the molecular mechanism of chemotherapeutic agents and drug-resistance in cancer and for physicians using chemotherapeutic agents. Additionally, this book will be a important educational source for PhD students specializing in cell biology, immunology and MD students interested in Oncology and Cancer Therapeutics.


Cell death, apoptosis, cancer research,Khosravi-Far apoptosis cell biology regulation tumorigenesis

Authors and affiliations

  1. 1.Department of PathologyHarvard Medical School, Beth Israel Deaconess Medical CenterBostonUSA
  2. 2.Center for Advanced Biotechnology and Medicine; Department of Molecular Biology and BiochemistryRutgers UniversityPiscatawayUSA
  3. 3.Cancer Institute of New JerseyNew BrunswickUSA

Bibliographic information

Industry Sectors
Health & Hospitals
Oncology & Hematology
Consumer Packaged Goods


From the reviews:

"Programmed cell death (PCD) is an intriguing term that was introduced by Richard Lockshin nearly 45 years ago. … this book is about PCD with intense focus on apoptosis and the exploitation of PCD for treating cancer. … All chapters are well edited and thoroughly referenced. The nicety of the book is the use of numerous color figures. In my opinion, both scientists and clinicians, experienced or beginning, will profit from a thoughtful reading of Programmed Cell Death in Cancer Progression and Therapy." (A. A. Philchenkov, Biochemistry (Moscow), Vol. 74 (4), 2009)