© 2007

Intramembrane-Cleaving Proteases (I-CLiPs)

  • Nigel M. Hooper
  • Uwe Lendeckel
  • First book to deal with this emerging group of proteases

  • Comprehensive review of the current state of research on I-CLiPs

  • Contributions by authors recognised as leaders in their fields

  • Easy to read descriptive text


Part of the Proteases in Biology and Disease book series (PBAD, volume 6)

Table of contents

  1. Front Matter
    Pages I-IX
  2. Robert B. Rawson, Wei-ping Li
    Pages 1-15
  3. Todd E. Golde, Criag Zwizinski, Andrew Nyborg
    Pages 17-30
  4. Harald Steiner, Christian Haass
    Pages 31-49
  5. Sinisa Urban
    Pages 51-77
  6. Michael S. Wolfe
    Pages 89-109
  7. Ma. Xenia G. Ilagan, Dilip Chandu, Raphael Kopan
    Pages 111-140
  8. Back Matter
    Pages 141-142

About this book


In recent years a growing number of proteases have been identified that catalyse peptide bond hydrolysis in the plane of the cellular membrane. These so-called ‘intramembrane-cleaving proteases’ (I-CLiPs) are involved in a diverse range of cellular processes, including cell regulation, signalling, quorum sensing, protein processing, lipid metabolism and the unfolded protein response. Some I-CLiPs play critical roles in diseases such as Alzheimer’s and viral infection. The authors, who are all world leaders in this exciting field of cell biology, provide an overview of the various proteases including recent data derived from the structural determination of some of the I-CliPs, and discuss the various roles that these proteases play in biology and disease. The aim of this book is to provide an update on this emerging group of unusual but important proteases for both the specialist and those with a broader interest in proteases. Amongst the target audience will be protease researchers, enzymologists, those working in academia and the pharmaceutical industry on biological processes and diseases involving I-CLiPs.


Alzheimer's Biological Membrane Cell Signalling Lipid Metabolism Protease Termination saccharomyces cerevisiae

Editors and affiliations

  • Nigel M. Hooper
    • 1
  • Uwe Lendeckel
    • 2
  1. 1.University of LeedsLeedsUnited Kingdom
  2. 2.Otto-von-Guericke UniversitätMagdeburgGermany

Bibliographic information

Industry Sectors
Health & Hospitals