© 2007

Peroxiredoxin Systems

Structures and Functions

  • Leopold Flohé
  • J. Robin Harris
  • First authoritative compilation in book form on the peroxiredoxins

  • Chapters contributed by top experts in their field of study

  • Contains a broad survey of all significant aspects of the peroxiredoxins

  • For the first time the book brings clarity into a field that, for historical reasons, has so far been extremely confused

  • Links the emerging field to related topics of biochemistry and physiology


Part of the Subcellular Biochemistry book series (SCBI, volume 44)

Table of contents

  1. Front Matter
    Pages I-XIV
  2. Leopold Flohé, J. Robin Harris
    Pages 1-25
  3. Bernard Knoops, ElÉonore Loumaye, ValÉrie Van Der Eecken
    Pages 27-40
  4. P. Andrew Karplus, Andrea Hall
    Pages 41-60
  5. Leslie B. Poole
    Pages 61-81
  6. Madia Trujillo, Gerardo Ferrer-Sueta, Leonor Thomson, Leopold Flohé, Rafael Radi
    Pages 83-113
  7. Thomas J. Jönsson, W. Todd Lowther
    Pages 115-141
  8. James M. Dubbs, Skorn Mongkolsuk
    Pages 143-193
  9. Timo Jaeger
    Pages 207-217
  10. Marcel Deponte, Stefan Rahlfs, Katja Becker
    Pages 219-229
  11. Luise R. Krauth-Siegel, Marcelo A. Comini, Tanja Schlecker
    Pages 231-251
  12. Brian A. Morgan, Elizabeth A. Veal
    Pages 253-265
  13. Zhenbo Cao, J. Gordon Lindsay, Neil W. Isaacs
    Pages 295-315
  14. Bruno Schremmer, Yefim Manevich, Sheldon I. Feinstein, Aron B. Fisher
    Pages 317-344
  15. Isabelle Donnay, Bernard Knoops
    Pages 345-355
  16. Fumiyuki Hattori, Shinzo Oikawa
    Pages 357-374
  17. Tetsuro Ishii, Toru Yanagawa
    Pages 375-384
  18. Back Matter
    Pages 385-389

About this book


A volume within the Subcellular Biochemistry series is an appropriate setting for the first multi-author book devoted to the new family of antioxidant and cell signalling proteins, the peroxiredoxins. Within the antioxidant and cell signalling fields, even the existence of the peroxiredoxins has yet to be appreciated by many; with this book we aim to rectify this situation. We have tried to select diverse chapter topics to cover relevant aspects of the subject and to persuade knowledgeable authors to contribute a manuscript. As almost inevitable, a few authors let us down by failing to respond, others could not submit a manuscript in time for personal reasons. These unfortunately were two of the pioneers, Earl Stadtman and Sue Goo Rhee, but we appreciate that they communicated a lot of details that helped us to reconstruct the early phase of peroxiredoxin enzymology. We have thus compiled a book that competently covers the peroxiredoxin field from its beginnings through to currently relevant topics. In the introductory Chapter 1 we provide a short historical survey of the subject, based upon the early structural and enzymic studies on peroxiredoxins, and then lead into some of our current personal interests, such as the likely continuing contribution of transmission electron microscopy (TEM) for the study of high molecular mass peroxiredoxin complexes and the association of peroxiredoxins with other proteins, and the targeting of drugs against microbial peroxiredoxins, as future therapeutic approaches.


Antioxidant Cell Signalling Oxidant Stress Peroxiredoxin Protozoa Thioredozin Peroxidase cellular processes hydrogen peroxide micro-organism mycobacteria parasites protein protein family proteins regulation

Editors and affiliations

  • Leopold Flohé
    • 1
  • J. Robin Harris
    • 2
  1. 1.MOLISA GmbH MagdeburgMagdeburgGermany
  2. 2.University of MainzMainzGermany

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