© 2007

Quality of Life Impairment in Schizophrenia, Mood and Anxiety Disorders

New Perspectives on Research and Treatment

  • Michael S. Ritsner
  • A. George Awad
  • The Distress/Protection Vulnerability model of HRQL impairment

  • New insights from neuroscience

  • Integrative approach to quality of life measurement

  • Comparative data regarding severe mental disorders

  • Treatment and Rehabilitation Issues


Table of contents

  1. Front Matter
    Pages I-XIV
  2. Key Methodological Issues

  3. Quality of Life Impairment Syndrome in Severe Mental Disorders

    1. Front Matter
      Pages 157-157
    2. Andreas Bechdolf, Verena Veith, Ralf Pukrop, Joachim Klosterkötter
      Pages 159-171
    3. Michael S. Ritsner, Anatoly Gibel
      Pages 173-226
    4. Paul H. Lysaker, Shira Louria
      Pages 227-240
    5. Marcelo T. Berlim, Marcelo P.A. Fleck
      Pages 241-252
    6. Erin E. Michalak, Greg Murray, Allan H. Young, Raymond W. Lam
      Pages 253-274
    7. Margaret A. Koury, Mark Hyman Rapaport
      Pages 275-291
    8. Julio Bobes, M.-P. GarcÍa-Portilla, Maria-Teresa BascarÁn, Pilar-Alejandra SÁiz, Maria-Teresa Bobes-BascarÁn, Manuel BousoÑo
      Pages 293-303
  4. Treatment and Rehabilitation Issues

    1. Front Matter
      Pages 305-305
    2. A. George Awad, Lakshmi N.P. Voruganti
      Pages 307-319

About this book


Over the past few decades health-related quality of life (HRQL) has emerged as the new image of medicine viewed from a psychosocial perspective. The concept of Quality of Life has attracted a good deal of interest, not only from a clinical perspective but also from psychosocial, health economics as well as cultural aspects. More recently, the neurobiological brain substrates that modulate many aspects of subjective experiences, which is relevant to quality of life such as affect, mood, cognition, pleasure, reward responses as well as feeling of wellbeing and satisfaction has been explored and elucidated. Such increased interest in HRQL is highlighted by the large number of recent publications. Over the past 10 years at least 350 papers were published describing aspects of HRQL in the psychiatric and mental field. Among them 78% dealt with HRQL in schizophrenia and schizoaffective disorders, 21% with major depression, 14% with anxiety disorders and 4% with bipolar disorder. It is gratifying to witness the enhanced interest and popularity in HRQL research and publications, yet the field continues to suffer from conceptual inconsistencies as well as a good deal of methodological limitations. It is worrisome that we still do not have a clear understanding of the concept itself as applied to mental health and illness as well as the complex array of its determinants. Similarly there is a lag in the application of quality of life data in improving clinical practice.


Assessment Depression Emotion Psychopharmacology Rehabilitation Syndrom anxiety

Editors and affiliations

  • Michael S. Ritsner
    • 1
    • 2
    • 3
  • A. George Awad
    • 4
    • 5
  1. 1.Associate Professor, Department of Psychiatry, Faculty of MedicineTechnion - Israel Institute of TechnologyHaifa
  2. 2.Director, Acute Department, Sha’ar MenasheMental Health CenterIsrael
  3. 3.Associate Editor, Quality of Life ResearchAmsterdamThe Netherlands
  4. 4.Professor Emeritus, Department of PsychiatryInstitute of Medical Science University of Toronto Chief of PsychiatryHumber River Regional HospitalToronto
  5. 5.Ontario President, The International Society of CNSClinical Trials and MethodologyCanada

Bibliographic information

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From the reviews:

"Health-related quality of life (HRQOL) is certainly a construct with legs. … The editors are very successful in covering a broad scope of information, allowing readers … to fill in the gaps of their understanding about HRQOL concepts and methodology. This may be the greatest contribution of this book … . There are a number of wonderful chapters that many researchers will find quite useful. … I’m glad to have this resource in my library and will recommend it to my colleagues." (Charles E. Drebing, PsycCRITIQUES, Vol. 53 (13), 2008)

"The best cumulative work on the topic of health-related quality of life (HRQL) with regard to severe mental health diagnoses. … This collaborative text adds to the knowledge about HRQL and encourages the reader to consider quality of life as a measurement of success. … Technically, the book is well written and edited as well as attractively printed. … it will be useful for all researchers of quality-of-life issues and particularly so for specialists in behavioral health." (Mark H. Fleisher, JAMA, Vol. 300 (4), July, 2008)