© 2004

Myb Transcription Factors: Their Role in Growth, Differentiation and Disease

  • Jon Frampton

Part of the Proteins and Cell Regulation book series (PROR, volume 2)

Table of contents

  1. Front Matter
    Pages i-xxxi
  2. Colin Davidson, Emily Ray, Joseph Lipsick
    Pages 1-33
  3. Alisa L. Katzen
    Pages 35-64
  4. Alexandros Vegiopoulos, Nikla R. Emambokus, Jon Frampton
    Pages 107-131
  5. Sandrine Sarrazin, Michael H. Sieweke
    Pages 133-144
  6. Ramana V. Tantravahi, Stacey J. Baker, E. Premkumar Reddy
    Pages 163-179
  7. Fiona J. Tavner
    Pages 201-221
  8. Kazuhiro Ogata, Tahir H. Tahirov, Shunsuke Ishii
    Pages 223-238
  9. Xianming Mo, Elisabeth Kowenz-Leutz, Achim Leutz
    Pages 239-256
  10. Karl-Heinz Klempnauer
    Pages 257-270
  11. Scott A. Ness
    Pages 271-278
  12. Fan Liu, Scott A. Ness
    Pages 279-306
  13. Juraj Bies, Linda Wolff
    Pages 307-329
  14. Cathy M. Holt, Nadim Malik
    Pages 331-349
  15. Claudia S. Hofmann, Gail E. Sonenshein
    Pages 351-366
  16. Robert G. Ramsay, Daniel Ciznadji, Gabriella Zupi
    Pages 367-388

About this book


This volume represents the first collection of articles contributed by research leaders working on the Myb family of transcriptional regulatory proteins. In more than twenty chapters the authors discuss the range of biological processes and diverse cell types in which Myb proteins operate. Although concentrating on the three vertebrate Myb family members, homologues from lower species are also discussed because of the light they are able to shed on the evolution and function of these proteins. Individual chapters describe the involvement of Myb proteins, in particular c-Myb, in normal and diseased development and function of many tissues including haemopoietic cells, blood vessels, the gastrointestinal tract and the brain. Several chapters explore the mechanistic details of the action of Myb proteins, especially structural features, their interaction with DNA and other regulatory proteins, and the variety of genes that are regulatory targets for this group of transcription factors. This work will be of interest to those working directly in the field and also to the wider research community investigating the transcriptional regulation of development, differentiation and growth. The therapeutic potential of manipulating Myb function is also discussed making the book appealing to clinician scientists in several fields including haematology, oncology and cardiology.


GENECELL carcinogenesis cell development DNA gene expression genes microarray oncogene oncology protein proteins stem cell T cell tissue transcription

Editors and affiliations

  • Jon Frampton
    • 1
  1. 1.Institute for Biomedical Research, Birmingham University Medical SchoolUK

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