© 2004

Bone Metastasis and Molecular Mechanisms


  • Gurmit Singh
  • William Orr
  • Provides an overview of molecular factors that offer targets and avenues for therapeutic strategies


Part of the Cancer Metastasis — Biology and Treatment book series (CMBT, volume 6)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Belinda S. Parker, Bedrich L. Eckhardt, Robin L. Anderson
    Pages 1-18
  3. Julie A. Sharp, Erik W. Thompson
    Pages 19-30
  4. Snezana Vukmirovic-Popovic, Eric Seidlitz, F. William Orr, Gurmit Singh
    Pages 31-48
  5. Michael H. Weber, Jonathan C. Sharp, Thomas H. Hassard, Martin Reed, James A. Thliveris, F. William Orr
    Pages 49-69
  6. Paolo Bianco, Mara Riminucci, Pamela Gehron Robey
    Pages 71-85
  7. Linda M. Pilarski, Tony Reiman, Patrick M. Pilarski, F. William Orr, Andrew R. Belch
    Pages 109-138
  8. Shafaat A. Rabbani, Nicholas Shukeir, Andrew P. Mazar
    Pages 163-186
  9. Sadmeet Singh, Gurmit Singh
    Pages 187-210
  10. Wilhelmina C. M. Duivenvoorden, Gurmit Singh
    Pages 241-276
  11. Mary MacKenzie, Pierre Major
    Pages 277-301
  12. Back Matter
    Pages 303-308

About this book


Patients with advanced breast or prostate cancers usually develop bone metastases. The principal complications resulting from metastatic bone disease are pain, spinal cord compression, pathologic fractures and bone marrow suppression. Improving the management of bone metastases is crucial to quality of life for patients with breast and prostate cancer.

Advances in understanding of the molecular mechanisms underlying the pathophysiology of bone metastasis are driving the development of new therapeutic strategies.


angiogenesis bisphosphonates bone marrow cancer macrophages metastasis pain pathophysiology prostate cancer

Editors and affiliations

  • Gurmit Singh
    • 1
  • William Orr
    • 2
  1. 1.Juravinski Cancer CentreMcMaster UniversityHamiltonCanada
  2. 2.Department of PathologyUniversity of ManitobaWinnipegCanada

Bibliographic information

  • Book Title Bone Metastasis and Molecular Mechanisms
  • Book Subtitle Pathophysiology
  • Editors Gurmit Singh
    William Orr
  • Series Title Cancer Metastasis — Biology and Treatment
  • DOI
  • Copyright Information Springer Science+Business Media Dordrecht 2004
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-1-4020-1984-5
  • Softcover ISBN 978-90-481-6563-6
  • eBook ISBN 978-1-4020-2036-0
  • Series ISSN 1568-2102
  • Edition Number 1
  • Number of Pages XVI, 308
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Oncology
    Cancer Research
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Oncology & Hematology