Table of contents

  1. Front Matter
    Pages i-ix
  2. T. P. Flores, D. S. Moss
    Pages 1-26
  3. Leo S. D. Caves, Dzung T. Nguyen, Roderick E. Hubbard
    Pages 27-68
  4. Arun Malhotra, Robert K.-Z. Tan, Stephen C. Harvey
    Pages 107-136
  5. Mark A. Williams, Mansoor A. S. Saqi, Julia M. Goodfellow
    Pages 179-195
  6. Back Matter
    Pages 197-200

About this book


Molecular dynamics is an important technique with applications in many areas including those of drug design, protein engineering, macromolecular structure determination and molecular recognition. This book concentrates on these exciting applications while summarizing briefly the essential mathematical background. Results are presented on protein, carbohydrate and nucleotide modelling and dynamics using the standard molecular dynamics and related algorithms. There are also chapters covering two relatively new applications namely the simulated annealing protocol which has revolutionized macromolecular structure determination from both nmr spectroscopy and x-ray crystallography and the free energy perturbation method with its direct applications relevant to the design of drugs and mutant proteins.


biology drug design Hydra molecular biology nucleic acid Nucleotide protein protein engineering proteins RNA spectroscopy

Editors and affiliations

  • Julia M. Goodfellow
    • 1
  1. 1.Dept of CrystallographyBirkbeck CollegeLondonUK

Bibliographic information

  • Book Title Molecular Dynamics
  • Book Subtitle Applications in Molecular Biology
  • Editors Julia M Goodfellow
  • Series Title Topics in Molecular and Structural Biology
  • DOI
  • Copyright Information Macmillan Publishers Limited 1991
  • Publisher Name Palgrave, London
  • eBook Packages Engineering Engineering (R0)
  • Hardcover ISBN 978-0-333-49886-6
  • Softcover ISBN 978-1-349-11046-9
  • eBook ISBN 978-1-349-11044-5
  • Edition Number 1
  • Number of Pages IX, 200
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Additional Information Previously published under the imprint Palgrave
  • Topics Molecular Medicine
    Cell Biology
    Biochemistry, general
  • Buy this book on publisher's site
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