© 2020

Role of the Choroid Plexus in Health and Disease

  • Jeppe Praetorius
  • Bonnie Blazer-Yost
  • Helle Damkier

Part of the Physiology in Health and Disease book series (PIHD)

Table of contents

  1. Front Matter
    Pages i-vi
  2. Helle Damkier, Jeppe Praetorius
    Pages 1-33
  3. Conrad E. Johanson, Richard F. Keep
    Pages 35-81
  4. Donald D. F. Loo, Ernest M. Wright
    Pages 83-97
  5. Lisa Juul Routhe, Maj Schneider Thomsen, Torben Moos
    Pages 125-148
  6. Dagne Barbuskaite, Helle Damkier, Jeppe Praetorius
    Pages 149-171
  7. Alexandra E. Hochstetler, Makenna M. Reed, Bonnie L. Blazer-Yost
    Pages 173-191
  8. Jean-Francois Ghersi-Egea, Alexandre Vasiljevic, Sandrine Blondel, Nathalie Strazielle
    Pages 193-207
  9. Caroline Van Cauwenberghe, Nina Gorlé, Roosmarijn E. Vandenbroucke
    Pages 209-232
  10. Daniel H. Fulkerson, Adam Leibold, David Priemer, Karl Balsara
    Pages 233-250
  11. Christian Schwerk, Tobias Tenenbaum, Horst Schroten
    Pages 251-269
  12. Marianne Juhler
    Pages 271-287

About this book


This book highlights the importance of the choroid plexus, which forms the blood-cerebrospinal fluid barrier and is the site of the major production of the cerebrospinal fluid (CSF). The authors show that this barrier is crucial for maintaining important compositional differences between the blood plasma and the CSF. The choroid plexus epithelial cells also prevent the spread of infectious agents and other blood-borne entities to the brain tissue. 

Chapter topics range from the production of CSF by electrolyte regulation in the choroid plexus, to details on the selectively transporting nature of this barrier. Further, the authors elaborate on the important roles of CSF in sustaining brain health by providing hydration, solutes, and nutrients to the brain tissue. Readers will also learn how CSF circulates signaling molecules within the compartments of the brain and removes waste products from the brain tissue. Elucidating the regulation of these processes in the choroid plexus is not only important for the readers’ understanding of normal brain development and function, but is also crucial for resolving a variety of cerebral challenges that lead to brain edema, as well as developing treatments for diseases. The book discusses disease models like hydrocephalus, sleep disorders, and age-related dementia.

Its comprehensive coverage makes this volume a valuable resource for researchers in cell and neurophysiology, as well as graduate students of the neurosciences.


Alzheimers Disease Blood Cerebrospinal Fluid Barrier Brain Development Cerebrospinal Fluid Production Cerebrospinal Fluid (CFS) Production Hydrocephalus Regulated Ion Transport

Editors and affiliations

  • Jeppe Praetorius
    • 1
  • Bonnie Blazer-Yost
    • 2
  • Helle Damkier
    • 3
  1. 1.Department of Biomedicine, Faculty of HealthAarhus UniversityAarhusDenmark
  2. 2.Department of BiologyIndiana University – Purdue University IndianapolisIndianapolisUSA
  3. 3.Department of Biomedicine, Faculty of HealthAarhus UniversityAarhusDenmark

About the editors

Jeppe Praetorius

Department of Biomedicine

Aarhus University



Bonnie Blazer-Yost

Department of Biology

Indiana University – Purdue University Indianapolis




Helle Damkier

Department of Biomedicine

Aarhus University



Bibliographic information

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