Clinical and Preclinical Models for Maximizing Healthspan

Methods and Protocols

  • Paul C. Guest

Part of the Methods in Molecular Biology book series (MIMB, volume 2138)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Reviews

    1. Front Matter
      Pages 1-1
    2. Behnaz Abiri, Mohammadreza Vafa
      Pages 29-47
    3. Anne Poljak, Mark W. Duncan, Tharusha Jayasena, Perminder S. Sachdev
      Pages 49-81
    4. Ann-Katrin Kraeuter, Paul C. Guest, Zoltán Sarnyai
      Pages 83-98
  3. Protocols

    1. Front Matter
      Pages 99-99
    2. Yashar Mehrbani Azar, Maria Jacoba Kruger, Dalene de Swardt, Michelle Maartens, Ascentia Mathapelo Seboko, William Frank Ferris et al.
      Pages 119-134
    3. Aliza K. De Nobrega, Kristine V. Luz, Katherine N. Lyons, Lisa C. Lyons
      Pages 135-158
    4. Chareeporn Akekawatchai, Sittiruk Roytrakul, Narumon Phaonakrop, Janthima Jaresitthikunchai, Sarawut Jitrapakdee
      Pages 185-193
    5. Tharusha Jayasena, Sonia Bustamante, James Clement, Robert Welschinger, Gideon A. Caplan, Perminder S. Sachdev et al.
      Pages 207-216
    6. Maximus Berger, G. Paul Amminger, Robyn McDermott, Paul C. Guest, Zoltán Sarnyai
      Pages 233-242
    7. Paul C. Guest, Hans-Gert Bernstein, Henrik Dobrowolny, Katrin Borucki, Sabine Westphal, Johann Steiner
      Pages 251-262
    8. Robert Heaton, Kate Duberley, Iain P. Hargreaves
      Pages 277-287
    9. Justin Darcy, Chih-Hao Wang, Yu-Hua Tseng
      Pages 289-296
    10. Vasily V. Ashapkin, Lyudmila I. Kutueva, Boris F. Vanyushin
      Pages 297-312
    11. Idha Kusumawati, Kresma Oky Kurniawan, Subhan Rullyansyah, Eka Pramyrtha Hestianah
      Pages 313-321
    12. Fatemeh Haidari, Behnaz Abiri, Masood Iravani, Kambiz Ahmadi-Angali, Mohammadreza Vafa
      Pages 337-350
    13. Paul C. Guest, Hassan Rahmoune, Daniel Martins-de-Souza
      Pages 407-417
  4. Back Matter
    Pages 449-451

About this book


This book presents a series of protocols in multiple disease areas affected by the aging process along with several methods which have shown progress in nutrient- or intervention-based approaches to maximize the healthspan. Of interest to researchers in the areas of chronic disease, gerontology, physical exercise, and nutrition as well as to clinical scientists, physicians, and pharmacologists, this volume also provides important information on disease mechanisms and novel drug targets as each protocol will be presented in the context of specific chronic diseases or different therapeutic areas. Written for the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 

Authoritative and practical, Clinical and Preclinical Models for Maximizing Healthspan: Methods and Protocols is an ideal guide for preclinical and clinical researchers working toward the discoveries needed to lead to a world society in which individuals are not only living longer lives but more productive and healthier ones.


Chronic disease Gerontology Drug targets Epidemiology Aging process Disease mechanisms Healthcare improvement

Editors and affiliations

  • Paul C. Guest
    • 1
  1. 1.Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of BiologyUniversity of Campinas (UNICAMP)CampinasBrazil

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC, part of Springer Nature 2020
  • Publisher Name Humana, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-0716-0470-0
  • Online ISBN 978-1-0716-0471-7
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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