Cellular and Translational Approaches

  • Seng-Lai Tan

Part of the Methods in Pharmacology and Toxicology book series (MIPT)

Table of contents

  1. Front Matter
    Pages i-x
  2. Tomasz Dobrzycki, Andreea Ciuntu, Andrea Stacey, Joseph D. Dukes, Andrew D. Whale
    Pages 51-72
  3. Eden Kleiman, Wushouer Ouerkaxi, Marc Delcommenne, Geoffrey W. Stone, Paolo Serafini, Mayra Cruz Tleugabulova et al.
    Pages 73-88
  4. Lynne S. Dunsford, Rosie H. Thoirs, Emma Rathbone, Agapitos Patakas
    Pages 89-101
  5. Brad Larson, Lubna Hussain, Jenny Schroeder
    Pages 103-115
  6. Sofia P. Rebelo, Catarina Pinto, Nuno Lopes, Tatiana R. Martins, Paula Marques Alves, Catarina Brito
    Pages 117-130
  7. Jamison Grailer, Richard A. Moravec, Zhijie Jey Cheng, Manuela Grassi, Vanessa Ott, Frank Fan et al.
    Pages 131-156 Open Access
  8. Leanne Flye-Blakemore, Christèle Gonneau, Nithianandan Selliah, Ajay Grover, Sriram Ramanan, Alan Lackey et al.
    Pages 167-197
  9. Jinze Li, Mayur S. Mitra, Gautham K. Rao
    Pages 199-238
  10. Leonardo Mirandola, Franco Marincola, Gianluca Rotino, Jose A. Figueroa, Fabio Grizzi, Robert Bresalier et al.
    Pages 239-253
  11. Jamison Grailer, Richard A. Moravec, Zhijie Jey Cheng, Manuela Grassi, Vanessa Ott, Frank Fan et al.
    Pages C1-C1
  12. Back Matter
    Pages 255-262

About this book


This book serves as a guide for identifying and applying commonly used cell-based translational assays as well as for assessing the therapeutic potential of new immuno-oncology therapeutics and advancing their mechanism of action. The detailed chapters within will provide readers with a baseline understanding of the pros and cons as well as key considerations for applying assays that are more reflective of the human immune-tumor microenvironment in order to increase their translatability into the clinic. Written for the Methods in Pharmacology and Toxicology series, the contents of this volume include the kind of specifics and real-world implementation advice to ensure success in the lab. 

Authoritative and practical, Immuno-Oncology: Cellular and Translational Approaches aims to aid researchers working on biotechnology and pharmaceutical efforts to search for the next generation of safer and more effective cancer immunotherapeutics.

The chapter “Considerations in Developing Reporter Gene Bioassays for Biologics” is available open access under a Creative Commons Attribution 4.0 International License via


Cancer immunotherapy Drug discovery Cell-based translational assays Precision medicine Immune-tumor microenvironment Biosamples Immunotherapeutics

Editors and affiliations

  • Seng-Lai Tan
    • 1
  1. 1.Elstar TherapeuticsCambridgeUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC, part of Springer Nature 2020
  • Publisher Name Humana, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-0716-0170-9
  • Online ISBN 978-1-0716-0171-6
  • Series Print ISSN 1557-2153
  • Series Online ISSN 1940-6053
  • Buy this book on publisher's site
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