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Blood Cell Biochemistry

Hematopoietic Cell Growth Factors and Their Receptors

  • Anthony D. Whetton
  • John Gordon

Part of the Blood Cell Biochemistry book series (BLBI, volume 7)

Table of contents

  1. Front Matter
    Pages i-xxiii
  2. Anne-Marie O’Farrell, Taisei Kinoshita, Atsushi Miyajima
    Pages 1-40
  3. Andrew N. J. McKenzie, Andrew W. Heath
    Pages 41-50
  4. Margaret M. Harnett
    Pages 79-98
  5. Hal E. Broxmeyer
    Pages 121-150
  6. Rachel S. Chapman, Christopher D. Gregory, Caroline Dive
    Pages 151-201
  7. Mike Salmon, Darrell Pilling, Clair Mappin, Arne N. Akbar
    Pages 203-215
  8. Ana Cumano, Barbara L. Kee, Isabelle Godin, Françoise Dieterlen-Lièvre, C. J. Paige
    Pages 217-239
  9. Jacques Banchereau, Pierre Garrone, Yong-Jun Liu
    Pages 241-262
  10. Christophe Caux, Jacques Banchereau
    Pages 263-301
  11. Jan Tavernier, Geert Plaetinck, Yves Guisez, Jose van der Heyden, Johan Kips, Renaat Peleman et al.
    Pages 321-361
  12. Ian K. McNiece, Robert A. Briddell
    Pages 363-379
  13. Andrew Weaver, Nydia G. Testa
    Pages 381-413
  14. Back Matter
    Pages 415-419

About this book

Introduction

Historically, the field of hematopoietic growth factor research began with the work of Carnot and Deflandre-in 1906 they suggested that the rate of erythropoiesis is regulated by a humoral factor found in the blood, namely, erythropoietin. From this comparatively early start, accelerating progress has been made in erythropoietin research, which demon­ strates the general trends in this field of study. Erythropoietin was purified to homogeneity by 1977 (from enormous quantities of urine from aplastic anemia patients). Subsequently, the gene for erythropoietin has been cloned (1985), and massive quantities of this growth factor have been produced for clinical trials (late 1980s onward). Erythropoietin has become established as a pharmaceutical product of great value in the treatment of a number of diseases, most notably chronic renal failure. Once the ligand had been cloned, interest turned to the erythropoietin receptor, which was cloned in 1989. Since then, structure/ function studies have been performed on receptor mutants, cellular signaling events down­ stream from the occupied receptor have been identified, and the specific producer cell types and molecular stimuli for erythropoietin production have been thoroughly investigated, as has the regulation of erythropoietin gene transcription. This schedule of events since the 1970s typifies that seen for a number of hematopoietic growth factors. Along the way, the hematopoietic growth factors have been recognized as members of the cytokine family of signaling molecules that are important in a number of different physiological and patholog­ ical situations (see below).

Keywords

T cell apoptosis biochemistry blood cell cytokine cytokines hematopoiesis immune system leukemia lymphocytes receptor stem cell

Editors and affiliations

  • Anthony D. Whetton
    • 1
  • John Gordon
    • 2
  1. 1.Leukaemia Research Fund Cellular Development UnitUMISTManchesterEngland
  2. 2.The Medical SchoolUniversity of BirminghamBirminghamEngland

Bibliographic information

  • DOI https://doi.org/10.1007/978-0-585-31728-1
  • Copyright Information Springer-Verlag US 1996
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4757-7052-0
  • Online ISBN 978-0-585-31728-1
  • Series Print ISSN 1078-0491
  • Buy this book on publisher's site
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